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Objective: This study aims to see the development of tumor tissue in rats given the combination of ethanol extract of Moringa leaves (Moringa oleifera L.) and ethanol extract of papaya leaves (Carica papaya L.) as an alternative to increasing nutrition in slowing tumor tissue which will be used for further studies on phytotherapy as an alternative medicine for cancer. Methods: This study was conducted experimentally using a laboratory Complete Random Design (CRD) method. Results: The results show that there are different changes in body weight between groups for 12 weeks. However, based on the results of the one way ANOVA test, there is no significant differences between groups (p> 0.05). The appearance of tumor tissue was detected at week 7 in the comparison group (DMBA). Whereas in the positive control group and the combination extract group, the solid period began to be felt at the 10th week. Based on the results of histopathological tests in rat organs show that the growth of cancer tissue in all test animals in the treatment group given by DMBA. Conclusion: The combination from ethanol extract of Moringa leaves (Moringa oleifera L.) and ethanol extract of papaya leaves (Carica papaya L.) at a dose of 150 mg/kgBB has activity in slowing the formation of cancer tissue.