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Patient safety is the goal of patients service in assuring its quality. One of the strategy to design patients safety system is by recognizing potential errors, in order to take necessary measures to minimize the negative effect. Reporting system helps us to recognize and report error. The number of report for health service is still low, and it happens also in dr Soebandi Public Hospital in Jember. This study aims at determining the impact of nurses knowledge and motivation on their attitude in reporting patient safety incidents in dr Soebandi Public Hospital, Jember. This study was conducted on April – May 2018 employing quantitative research design with cross-sectional approach. Data were obtained by questionnaire given to 82 nurses working in dr. Soebandi Public Hospital in Jember. It was found out that there is a significant and positive effect of knowledge on attitude(t-statistic 3.613,koefisien direct effect 0.400), motivation on attitude(t-statistic 5.216, koefisien direct effect 0.473), knowledge on motivation(t-statistic 3.289, koefisien direct effect 0.434), knowledge on attitude through motivation (t-statistic 2.782, koefisien indirect effect 0.205). Knowledge is the most dominant factor influencing nurses attitude in reporting patients safety incidences in dr. Soebandi Public Hospital in Jember.