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Background: The 2012 SDKI data shows that 28% of girls and 24% of adolescent boys drink alcoholic beverages at the age of 15 years. About 2.8% of adolescents 15-19 years old are involved in drug abuse, and 0.7% of women and 4.5% of men aged 15-19 years have pre-marital sex. The 2012 SDKI results show that adolescent knowledge about reproductive health is inadequate. 41.2% of women and 55.3% of men aged 15-19 years knew that the method of transmission of HIV-AIDS could be reduced if having sex only with someone who did not have another partner. 46% of women and 60.8% of men aged 15-19 years know that HIV-AIDS transmission can be reduced by using condoms. Only 9.9% of women and 10.6% of men aged 15-19 have comprehensive knowledge of HIV-AIDS (PIK-KRR, 2014). Sex differences are an important factor in the use of substances and have been extensively studied. (Nagoshi et al, 2012). Purpose: To conclude and examine the literature relating to the management of reproductive health problems in adolescents oriented to gender equality and justice. Method: This Systematic Literature Review uses the Pubmed database with a period of 2008-2018. Selection of articles based on inclusion and exclusion criteria. Appraisal studies use the Critical Appraisal Skills Program (CASP), besides the synthesis method using PEOS. Results: Friendship, popular media that shape the perceptions and behavior of adolescents and young adults, the involvement of the community to promote healthy reproductive health and the Adolescent Pregnancy Prevention Program are the handling of adolescent reproductive health problems. Conclusion: Based on the results of handling reproductive health problems in adolescents that are oriented towards gender equality and justice, various kinds can be done but culture still has a major influence on reproductive health in adolescents.