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Human behavior affects pandemic HIV/AIDS transmission thereby preventive measure should be taken by considering behavioral factor. This research aimed to analyze the effectiveness of advocacy, and Information Education and Communication or IEC strategy in HIV/AIDS prevention in Surakarta Indonesia. This explorative study was conducted on Health Service, Surakarta AIDS Commission, NGOs caring about AIDS and people caring about AIDS selected using purposive sampling technique. Data was collected through participatory observation, in-depth interview, and documentation, validated using source triangulation, and analyzed using an interactive model of analysis with Parsons Functional Structural theory. Government, NGOs, and people caring about AIDS conducted HIV/AIDS transmission prevention comprehensively to mitigate individual and social effects, and to minimize HIV/AIDS stigmatization. Advocacy and IEC Team is established at all area levels and communities. Advocacy was conducted systematically using persuasive communication to related parties concerning anything related to HIV/AIDS prevention program to get policy and budget supports. This was followed-up with mass, group, and interpersonal IEC operational activities concerning HIV/AIDS knowledge, HIV/AIDS prevention to reduce vulnerability and to respect dignity and prestige of PLWHA. Advocacy and IEC of HIV/AIDS prevention should be conducted intensively by stakeholders, with supporting budget, facilities, method, and time.