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Abstract Objective: This research aimed to determine the effect of culture-based education in improving knowledge of hypertension patients in the Makassarese Community, Indonesia. Method: This study used a quasi-experiment with two groups pretest-posttest control group design. The sample was 36 respondents, which were divided into two groups, which were given culture-based education and control group is given ordinary education. Each group was given a pretest and posttest. Result: This study shows that there was an increasing knowledge of the intervention group after receiving cultural-based education. The research results showed t-value 1.92 with significant p-value > 0.005 with the mean values in the intervention group 27.78 and 11.67 in the control group. Conclusion: Education of culture-based hypertension affects increasing knowledge of people with hypertension in the community. Therefore, it is expected that culture-based education can be used as a health education program to increase the knowledge of hypertension patients effectively.