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ANTICANCER ACTIVITY of FIBRAUREA TINCTORIA WITH DLD1 CELLINE CYTOTOXICITY ASSAY
Riski Sulistiarini(a)*,(b), Andreanus A Soemardji(a) , Elfahmi(a) , Maria Immaculata Iwo (a) , Danang Waluyo (c), Dian Japany Puspitasari (c)

(a) School of Pharmacy, Bandung Institute of Technology, Jl. Ganesha 10 Bandung, Indonesia, 40132
kikyidris[at]gmail.com; riskisulistiarini[at]student.itb.ac.id
(b) Pharmacy Faculty of Mulawarman University, Jl. Gn. Kelua, Samarinda, East Borneo, Indonesia, 75243
(c) Biotech Center BPPT, Building 630 PUSPIPTEK Area, Setu, Tangerang Selatan, Banten 15314


Abstract

This study aims to determine the cytotoxic effects of Fibraurea tinctorial plants on DLD1 colon cancer cell lines in vitro and determine the IC50 values of these plants. The test begins with cell-line culture in the DMEM medium. Cultures that were ready with an estimated concentration in fresh media of 2.5x 104cells / 200uL were exposed to 0.4uL test material in 0.1% DMSO with concentrations starting at 6.25 ppm; 12.5 ppm; 25 ppm; 50 ppm; 100 ppm; 200ppm; 400ppm; 800ppm; and 1600ppm which was then incubated for 48 hours. The results are from methanol extract, hexane fraction, ethyl acetate fraction and HA and HB subfraction from Fibraurea tinctorial plants, only HB subfaction which shows inhibitory activity against DLD1 colon cancer cell line with 28% at 1600 ppm concentration

Keywords: Anticancer; dld1 Celline; Cytotoxicity Assay

Topic: Pharmaceutical Science

Link: https://ifory.id/abstract/qGF8garjmeRQ

Conference: The 2nd Health Science International Conference (HSIC 2019)

Plain Format | Corresponding Author (Riski Sulistiarini)

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