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Strategies for handling depression in divorced young adult has been scarely reported. Classical clinical evidences and international guidelines recommends psychotherapy management strategies, such as the cognitive behavioral approach, works well in handling and releasing from depressive conditions. The present case report aims to document and disseminate the treatment outcomes of the usefulness of Cognitive Behavioral Therapy for depression in reported case of a divorced young adult women. A brief clinical single case based report on the clinical manifestation, psychological assessment, therapeutic formulation and psychotherapeutic process on divorced young adult women (39 year old), diagnosed as DSM-V, with mild depression with somatic symptoms with onset usually occuring in young adulthood, referred to clinical psychologist for management. Based on a comprehensive psychiatry history taking, psychological assessment, and therapeutic formulation, Cognitive Behavioral Therapy for Depression (Miltenberger, 2008), was offered by professional psychology clinical master stundents guided by trained licensed clinical psychologist. Psychotherapy was given in 10 sessions, 60 minutes for each session within 5 weeks, and a follow-up of 3 monts. Symptoms were monitored for change by the therapist on 2 outcomes measures: Depression Anxiety Stress Scale and behavior observation during the process therapeutic. Clinical significant change (50% or above) based on pre- and post-therapy data scores on outcomes measures were used to assess the efficacy of the therapeutic intervention. Result indicate the intervention was effective for depression in a divorced young adult women. The challenges faced by the therapist in sensitive socio-cultural and limited client time, are discussed below.