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Laboratory operation requires relevant guidelines and standards to ascertain the halal laboratory to be accepted at the international level. Common worldwide guidelines and standards for laboratory are -International Organization for Standardization 17025- (ISO 17025), -Good Manufacturing Practice- (GMP), and -Good Laboratory Practice- (GLP). In halal analysis, the laboratory shall comply with ISO 17025, GMP, and -Good Hygiene Practice- (GHP) as stated in the -Manual Procedure for Malaysia Halal Certification- (MPPHM). This article predominantly discusses the basic requirement of laboratory operation, specifically for halal analysis. The study is based on a reliable primary source of several international guidelines and standards (ISO 17025, GMP, and GLP) as compared with -Malaysia Halal Standards-. The study shows that common worldwide guidelines and standards are components of halal laboratory with the addition of Islamic fundamental and practices. Consequently, the halal laboratory operates competently to generate a valid test result. Besides, the implication as such practice promotes confidence in the halal laboratory-s work both nationally and internationally, thus improves international trade.