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Introduction: Liver cancer is the sixth most common cancer and also the third highest cause of death caused by cancer. Failure in default therapy, side effects, and expensive cancer therapy lead researchers to be encouraged to look for effective and selective new cancer therapies. The aim of this study were to explored the effect of flavonoid active compound from clove leaf oil on liver cancer cells and its combination with standard drug for cancer therapy. Method: The cytotoxicity of active compound isolated from clove leaf oil and standard drug were analyzed on liver cancer cell culture and examines by MTT assay. The drug combination synergisms were indicated by the combination index (CI) using CompuSyn 1.4. Result: The results showed that flavonoid active compound from clove leaf oil in combination standard drug have Combinations Index below 1. Conclusion: It was concluded that flavonoid active compound from clove leaf oil were shown to have anticancer activity on liver cells culture and also have synergistic effect in combination with standard drug for cancer therapy.