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Ginger contains oleoresin and essential oils that can reduce the emesis of gravidarum in pregnancy. This research aims to determine the effect of giving ginger syrup on pregnant mothers to decrease the emesis gravidarum of the first trimester pregnant women. This study constituted quantitative research with quasi experiment. Design used was pretest-posttest. The samples in this research were 51 pregnant women divided into 3 groups, namely mothers who got ginger syrup, placebo, and motherrs who got B6. Implementation was carried out for 7 days. Data were analyzed using Chi Square,and Wilcoxon Test The results indicate the lowering of the frequency emesis gravidarum on the group given ginger syrup (p = 0,000), the group given placebo (p = 0.038), and the group given B6 (p = 0.003). The different mean value after 7 days of intervention are : Gingger syrup group (1.00 ± 0.00), Placebo group( 0.06 ± 0.01), and B6 group( 0.17 ± 0.1). The group given with ginger syrup is more effective to decrease the frequency of emesis gravidarum to the first trimester compared to B6 group and Placebo group.