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Dyslipidemia is a change in blood lipid profile level marked by an increase in total cholesterol, triglycerides, Low Densitity Lipoprotein (LDL) and decreased High Density Lipoprotein. The main trigger for changes in blood lipid profile is free radicals. Excessive and uncontrolled amounts of free radicals cause oxidative stress. In addition, an increase in free radicals in the body can cause a decrease in the activity of the enzyme lipoprotein lipase (LPL) which causes fat degeneration around cells. Being overweight can be caused by an increase in consumption of high-energy foods such as fat and carbohydrates accompanied by low physical activity. A diet high in fat and carbohydrates with less physical activity causes an increase in the rate of fat accumulation. Fat will be deposited peripherally and centrally, the accumulation of central fat triggers the process of lipolysis to produce free fatty acids. This study aims to determine the effect of high-fat feeding compared to standard feed (Rat Bio) on the body weight of dyslipidemic white rats. The research was conducted during June-November 2019 in the Biomedical Laboratory of Dentistry Faculty University of Jember. This research method is experimental with pre-post control group design. The subjects were 10 male Wistar white rats. White rats were divided into 2 groups: control and treatment. The control group was given the standard Rat Bio diet while the treatment group was given modified diet (High fat Modified diet and cattle brain sonde) for 60 days. Statistical analysis using the T-Test. Paired T-Test results in the treatment group (High fat Modified diet and cattle brain sonde).