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Soil Transmitted Helminths (STH) is a worm of the intestinal nematode that is transmitted to humans through soil contaminated with feces. In STH infection, CD4 cells differentiate four types of T-helper cells, namely Th1, Th2, Th17, and Treg. Th2 cells secrete cytokines in the form of IL-4, IL-5, IL-9, and IL-13 which activate various mucosal epithelial cells, eosinophils, basophils, IgE production, mast cells, and goblet hyperplasia cells. Basophil cells and mast cells activated by IgE through crosslinked-high-affinity Fc receptors (FcRs) from IgE on the cell surface cause secretion from inflammatory mediators in the form of TNF-α, TGF-β, IL-1, IL-6, and mediators performed in the form of histamine and heparin which increase smooth-muscle-cell motility, so that it stimulates entry into the intestine and increases secretion by goblet-cells which will expose the worms out of the body. This type of research uses a case control. The total subjects were 40 farmers, consisting of 20 people infected with STH and 20 people not infected with STH in Sumberagung Hamlet, Gurah Sub-District and Janti Hamlet, Papar District, Kediri Regency. The results of this study showed no difference in the number of basophils in farmers infected and not infected with STH with a value of p=0.418 or p>0.05. There are differences in TNF-α levels in farmers infected and not infected with STH with a value of p=0.019 or p<0.05. TNF-α levels in farmers infected with STH are lower than those that are not infected because infections occur repeatedly and continuously that form immunotolerant