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Background : Determining etiological factors advances in diagnostic modalities sensitive and spesific to anxiety is of importance in its evaluation and treatment. The inflammatory hypothesis is one of the recent topics concerning anxiety and may provide insight into the pathogenesis of anxiety and ultimately production of more effective anxiety therapies. Method : We reviewed several studies to evalute contemporary concept concerning proinflammatory and their relationship to various disorder of anxiety and the use of anti-inflammatory therapies in the anxiety treatment. Results : Proinflammation cytokine have been found to influence the progression and severity of anxiey in different patients and diseases . Sudies have shown elevated serum levels of IL-6, IL-8, IL-10, IL-1β, TNF-α, and CRP in anxiety disorders. Systemic administration of lipopolisaccharide, which induces the expression of IL-1β and other inflammation cytokines in the brain cause anxiety in healthy subject. Anti-inflammatory treatment of anxiety may have adjuvant properties with current anxiety medications. Conclusion : There is significance evidence that inflammatory cytokines influence development of anxiety disorders.