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Background: Dyslipidemia is a medical condition that refers to an abnormal of blood lipids level, most common is hyperlipidemia. Elevation of blood lipid such as cholesterol, triglycerides, LDL cholesterol, or a low HDL cholesterol level induces disturbance of endothelial function. Endothelial dysfunction in dyslipidemia is in large part due to a reduced bioavailability of nitric oxide (NO) which is synthesized by endothelial nitric oxide synthase (eNOS) which will trigger the development of atherosclerosis, and increases the risk of coronary heart disease Purpose: The purpose of this study was to determine the relationship of lipid profiles of dyslipidemia with eNOS levels in coronary heart disease (CHD) patients Methods: This study design was a cross-sectional study. The sample in this study were 25 patients which diagnosed as coronary heart disease of outpatients in Department of Cardiology of a regional general hospital and fulfilled the inclusion and exclusion criteria. Fifteen healthy individuals who come for the general check-up were included as a control group. Blood samples were collected for measurements of eNOS levels and lipid profiles that carried out according to laboratory standards. Statistical analyses were conducted using ANOVA and Shapiro-Wilk-test. Results: The results of this study showed that eNOS levels in the group of CHD patients (24,174±7,136 ng/ml) were significantly lower (p < 0.05) than those in the control group (72,092±30,065 ng/ml). The mean of triglycerides and HDL levels has a weak correlation with the level of eNOS (p > 0,05). The mean of LDL level has moderately positive correlation with eNOS, while cholesterol has a moderate negative correlation with the level of eNOS (p > 0.05) Conclusion: High cholesterol levels and low LDL levels in dyslipidemia condition were correlated with endothelial nitric oxide synthase (eNOS), which has a protective function in coronary heart disease.