analysis in silico of aloe vera compound as antimelasma deis hikmawati, titiek Respati, yuniarti, lelly yuniarti
Fakultas Kedokteran Universitas Islam Bandung
Melasma is a predominant hyper melanosis disorder on the face, which is often experienced by middle-aged women. Melasma occurs due to the excessive melanin formation process. The target of melasma therapy is to inhibit melanocyte proliferation and melanosome formation, also increase melanosome degradation. The decreasing of the inflammatory response is a way to inhibit melanin formation. Conventional melasma therapy has some side effects such as erythema and burning, ochronosis, also depigmentation such as confetti. One of the natural ingredients that have the potential to be developed as anti melasma is aloe vera. This study aims to analyze the potential and target of Aloe vera protein as anti melasma. This study uses the In silico method using the pathway analysis method with Pubchem Software, Swiss Target Prediction, String and Cystoscope. The results show that of the many phytochemicals present in aloe, several phytochemical compounds are predicted to act and inhibit the formation of melanin Tyrosinase-related protein1 (TYRP1), EStrogen Receptor 1 (ESR1), Interleukin 10 (IL10), and inducible NO synthase INOS. The conclusion is in silico analysis, the active substance contained can inhibit the enzyme TYR1, and increase IL10 and suppress ESR1 and INOS.
Keywords: Keywords: Aloe vera, antimelasma, in silico, target protein tyrosinase,