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Abstract Objective: This study aimed to determine serum TNF-α levels in pregnant women with the risk of preeclampsia and those who have preeclampsia. Method: This research was a cross-sectional study and conducted in two maternal and child hospitals in Makassar, South Sulawesi, Indonesia, that is Pertiwi and Fatimah hospitals. As many as 86 pregnant women; 31 normal blood pressure, 26 high-risk preeclampsia and 29 preeclampsia pregnant women checked their blood pressure and then gave informed consent. TNF-α level was examined used Enzyme-linked immunosorbent assay (ELISA) in Hasanuddin University laboratorium. Pregnant women with antiplatelet therapy, infectious, and inflammatory diseases were excluded from the study. Data presented in the form of tables and narratives. The bivariate analysis presented in the form of a cross table between variables TNF α levels with pregnant women at risk for preeclampsia and preeclampsia and analyzed used Kruskal Wallis Test. Results: TNF-α levels in normal patients are 24.47 pg/ml, whereas those at the risk of preeclampsia appear two times higher than preeclampsia (57.052 pg/ml), pregnant women with preeclampsia have approximately five times higher levels than normal pregnant women (327.330 pg/ml) Conclusion: Increased levels of TNF have begun to occur during the high-risk phase and have increased very high during preeclampsia.