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Background: COPD patients will experience increased airflow resistance, air trapping, and pulmonary hyperinflation. This condition causes a decrease in FEV1 and symptoms of shortness will occur earlier. The purpose of this study was to explain the effect of autogenic training with pursed lips breathing on anxiety and FEV1 of COPD patients. Method: This research used Quasy Experiment with Pre-Post approach of control group design. The population of this research were PPOK patient in RSUD Kanjuruhan Kepanjen Malang Regency and RST dr.Soepraoen Malang. Sampling was done by Simple Random Sampling technique according to inclusion criteria with total of 40 patients. The autogenic training intervention with pursed lips breathing had done 3 times a week for 4 weeks. So the total exercise as much as 12 times. Instruments used to measure anxiety are Zung-Self Rating Anxiety Scale (SAS / SRAS) and FEV1 using spirometry. Data analysis using Paired t test, Wilcoxon and Multivariate Manova test. Result and Analysis: Multivariate test result Manova got significance value 0,021 (α 0,05). This means that autogenic training with pursed lips breathing is effective in reducing anxiety and increasing the value of FEV1 in COPD patients. Conclusion and Discussion: Autogenic training with pursed lips breathing can reduce anxiety and increase FEV1 values if done regularly and continuously. This suggests that the role of nurse as Nursing Agency in providing nursing care in patients with COPD.