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Exclusive breast milk and milk Formula : How is the difference in the decrease in bilirubin after administration of phototherapy to neonates with hyperbilirubinemia? Esri Rusminingsih(a*), Romadhani T.P (a), Winarni (c), Marwanti (a), Ambar Winarti (a), Supardi (a), Chori Elsera (b) (a*) Departement of Medical Surgical Nursing,Institute of Health Science Muhammadiyah Klaten , Central Java. Indonesia Email : esrirusminingsih@yahoo.co.id (a) Departement of Medical Surgical Nursing,Institute of Health Science Muhammadiyah Klaten , Central Java. Indonesia (a) Departement of maternity Nursing,Institute of Health Science Muhammadiyah Klaten , Central Java. Indonesia. (c) Division of Neonatology, Muhammadiyah Hospital of Delanggu, Central Java, Indonesia Background: Increased hemolysis in neonates after birth increases the amount of unconjugated bilirubin. Low levels of glucoronyl transferase cause the baby cannot metabolize an increase in the load of unconjugated bilirubin resulting in hyperbilirubinemia. High levels of bilirubin can cause acute enchelopathy and in extreme conditions can cause Kern Jaundice. Hyperbilirubinemia in neonates requires medical treatment with phototherapy. Objective: To determine differences in bilirubin levels in neonates who received exclusive breastfeeding with neonates who received formula after phototherapy. Study design: This study used a retrospective study to look at changes in Total Serum Bilirubin (TSB) before and after phototherapy for 2 x 24 hours in neonates who exclusively breastfed and neonates with formula milk. Data was obtained from medical records during 2017. The number of samples was 23 neonates with ASI and 22 neonates with formula milk. Results: The results showed that the average age of the neonate was 5.22 days, the average TSB in neonates with ASI 17.01 mg / dl, and neonates with formula milk 16.22 mg / dl. After phototherapy, the average TSB in neonates with breast milk was 10.19 mg / dl, while neonates with formula milk 5.19 mg / dl. There were differences in TSB in neonates with breast milk and formula milk who received phototherapy (p <0.05). Conclusions: There was a significant reduction in TSB in exclusive breastfeeding neonates and neonates with formula milk. However, in neonates who received formula milk, a decrease in TSB was higher compared to neonates who exclusively breastfed. Keywords: Hyperbilirubinemia, Phototherapy, Total bilirubin serum, Exclusive breastfeeding, Formula milk, Neonates