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Abstract Objective: To prove the increasing of salivary HBD2 level in DMT2 patients, and to analyze its correlation with the number of colonies of C.Albicans species in the oral cavity DMT2 patients. Methods: This study was an analytic observational with Cross Sectional design and was done by taking saliva of DMT2 patients by spitting method to calculate HBD2 level and test with ELISA kit. To find out the number of C.Albicans colonies, a swab method was performed on the patients mucosa to be identified under a microscope and developed using 3 methods: DIRECT, Carbohydrate fermentation test and urea hydrolysis test. Results: ELISA test results showed that HBD2 levels increased significantly in the saliva of DMT2 patients compare the control (non DM) group, whereas the number of C.Albicans colonies did not differ significantly between the groups. Conclusion: HBD2 levels in saliva of DMT2 patients increased compared with non-DM samples, and the number of C.Albicans colonies found over 100 CFU in three sample groups.