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Abstract Objective: This study aims to describe the lifestyle of fishermen (men) who have activities at sea and housewives (women) who live at home, which in turn affects the avoidance of men and the threat of homemakers from the symptoms of diabetes. The research also explains the formation of the division of roles the socio-economic of the fishing community in the context of its socio-cultural influence. Method: This research employs a qualitative ethnographic method which was located in Bontosua Village, Pangkep Regency, South Sulawesi Province. Results: The results show that the strict social and economic division between men and women is based on the perception of maritime culture that understood the sea as a dangerous environment and working with heavy and complicated technology. To adapt to the conditions of nature and work, then, men who are assumed to be physically active at sea, while since women are physically weak so they live on land to do a variety of jobs that are relatively light and safe mainly domestic matters. Conclusion: For women, the lack of activity at home provides an opportunity to consume various kinds of favorite foods, including those that have the value and cultural meaning (Buginese, Makassar ethnicities) without realize that these foods are classified as high-risk foods that cause diabetes.