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Abstract Objective: This study aimed to examine whether honey and propolis Trigona are able to reduce level of leptin in central obesity human. Methods: It was a quasi-experimental study, population and sample were central obesity and normal weight as control. Sample size was 30 participants taken using purposive sampling. Results: Intervention as long as 14 days make an increased level of leptin as many as 97.076 Pg/ml in control group and decreasing respectively 171.803 Pg/ml and 245.293 Pg/ml in honey and propolis intervention group, both significant statistically. The dose of honey given was 105 mg/days divided into 3 packs, each pack contains 35 mg. The dose of propolis was 60 mg/days and divided into 3 capsules, each of it contains 20 mg. Intervention as long as 14 days and leptin levels examined using human ELISA Kit three times, that is before intervention, 7 days after intervention and 14 days after intervention. Conclusion: Honey and propolis Trigona has the ability to decrease leptin level of central obesity participants. These honey bee products are potential to be a dietary supplement for central obesity patients.