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Abstract Objective: To determine maximum inhibition of siwak extract against Aggregatibacter actinomycetemcomitans. Method: This study was an experimental laboratory with post-test only control group design. The study sample was Aggregatibacter actinomycetemcomitans in MHA medium. Total 24 samples were divided into 6 treatment groups, 5 groups of siwak-s extract with different concentration, 3.125%, 6.25%, 12.5%, 25%, 50% and 1 treatment group with DMSO control 5%. The inhibitory zone was measured after 48 hours incubation at 37 ° using calipers. Data analysis was performed with the Kruskal Wallis test. Results: The average diameter of inhibition zones at concentrations 3.125%, 6.25%, 12.5%, 25%, and 50% were 6.4 mm, 7.0 mm, 7.2 mm, 7.9 mm, and 8.6 mm, respectively. Conclusion: The maximum inhibition of siwak extract that can inhibit the growth of Aggregatibacter actinomycetemcomitans bacteria as one of the pathogenic bacteria that causes periodontal disease was siwak extract with a concentration of 50%