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Abstract Growth performance and immune responses of Asian seabass (Lates calcarifer) was assessed after being fed diet containing different levels of a commercial nucleotide (Optimun®) and a purified mixture of nucleotides containing AMP (Adenosine monophosphate), IMP (Inosine monophosphate), UMP (Uridine monophosphate), GMP (Guanidine monophosphate) and CMP (Cytidine monophosphate) at equal amounts. Six nucleotide supplemented diets and a control diet were used in this study namely O1 (Optimun 0.25%), O2 (Optimun 0.5%), O3 (Optimun 0.75%), P1 (0.25% nucleotides), P2 (0.5% nucleotides), P3 (0.75% nucleotide) and C (control/no supplemented nucleotides). Juvenile Asian seabass with an average weight of 13.19 ± 0.58 g (mean ± SD) were fed the treatment diet at 3% body weight per day for six weeks. The study revealed that the different inclusion level of nucleotide did not significantly affect the growth and immune responses of Asian seabass. However, diet P2 with supplementation of 0.5% nucleotide gave higher growth performance, serum total protein, albumin and globulin compare to other diet groups.