Indonesia Conference Directory

Corresponding Author
Shendi Suryana

Institutions
Universitas Garut

Abstract
Theophylline, salbutamol sulfate and glycerylguaiacolate are active substances for treat asthma (dyspnoea). Combination theophylline, salbutamol sulfate and glycerylguaiacolate in drug preparation have to produce pharmacological effect, so the drug preparation needs the quality assurance of product. This study aims to determine theophylline, salbutamol sulfate and glycerylguaiacolate using ultraviolet spectrophotometry derivative. Research has been conducted in syrup was analyzed using zero crossing wavelength method. NaOH 0,1 N was selected as the solvent. Zero crossing wavelength of theophylline is 275 nm on the first derivative, salbutamol sulfate 262 nm on the second derivative and glycerylguaiacolate 243 nm on the second derivative. Results showed that the recovery of theophylline and glycerylguaiacolate are between 112,913%-118,353% and 116,129%-117,655%, respectively, while the relative standard deviation between 1,090%-1,903% for theophylline and 1,013%-1,922% for glycerylguaiacolate. Limit of detection of theophylline and glycerylguaiacolate are 1,626 ppm and 6,375 ppm, respectively while limit of quantification are 4,927 ppm and 19,319 ppm. So, it concluded that this method could be applied to determine theophylline and glycerylguaiacolate in syrup mixture.

Keywords
Theophylline, salbutamol sulfate, glycerylguaiacolate, ultraviolet spectrophotometry derivative, zero crossing.

Topic
Chemistry

Link: https://ifory.id/abstract/bt2wPWnkEL6R

Corresponding Author
Syifa Fauziyah

Institutions
UNIVERSITAS NEGERI JAKARTA

Abstract
This study aims to develop innovative learning media that is mobile. Learning and knowing the quality of media are produced and see the feasibility of media to be used in learning on buffer solutions. This research was conducted at SMAN 107 Jakarta and SMAN 42 Jakarta starting in January 2018 until May 2018. The research method used is Research and Development which includes four stages, namely: (1) needs analysis, (2) development of mobile learning media, (3) Feasibility and trial test. Media that generates an android-based smartphone (smartphone) application called ChemBuff is 167MB compatible on Android devices up to v.7.1 Nougat with features such as material, video and educational features about the solution buffer. Based on the feasibility test It can be concluded that the mobile learning media that has been developed is feasible and practical for use in learning material buffer solutions. The test solution is that there is a very significant difference between the pre-test and post-test results.

Keywords
Mobile Learning, Buffer Solution

Topic
Chemistry

Link: https://ifory.id/abstract/urNvWhVYyaTR

Corresponding Author
Syifa Fauziyah

Institutions
UNIVERSITAS NEGERI JAKARTA

Abstract
The aim of this research is to (1) make a Mobile Media Learning on Acid and Base and to determine the quality of the media produced, (2) determine the feasibility of the media used in learning process. The subjects of this research were students of SMAN 54 Jakarta, SMAN 42 Jakarta, and 7 chemistry teachers. The research was conducted from January to May 2018. The method used in this research is Research and Development (R&D). The steps performed in this research are: (1) needs analysis, (2) developing mobile learning, (3) validation test of mobile learning media, (4) media testing by students and small scale of teachers, (5) media trials by students and teachers on a large scale. The results obtained from expert validation tests, small class trials, large class trials, and effectiveness of the media, it can be concluded that the mobile media learning developed in this research is good enough to use in the learning process. The n-gain value obtained from the effectiveness test is 0.76 which can be categorized as high effectiveness, based on the Paired t-test the Tcount value is 28.048. The paired t-test value is Tcount>Ttable (2.03), the value of significance obtained from the paired t-test is 0.000 which is less than the level of significance (α) = 0,05, therefore H0 is rejected so it can be concluded that there is a significant difference between pre-test score and post-test score. That difference means that there is improvement in students average score after using the mobile media learning.

Keywords
Mobile Learning, Acid and Bases

Topic
Chemistry

Link: https://ifory.id/abstract/Y4KcdgQWBVjx

Corresponding Author
Ai Mahmudatussa\-adah

Institutions
1Universitas Pendidikan Indonesia, Bandung Indonesia
2Institut Teknologi Bandung, Bandung Indonesia

Corresponding autor : aims[at]upi.edu

Abstract
ABSTRACT Purple sweet potato (Ipomoea batatas L) contains many acylated anthocyanins which are beneficial for human health. Purple sweet potato roots are easily damaged due to the high water and nutrient content. To extend the shelf life of purple sweet potatoes can be done by a drying process. The drying process can affect the color and amount of anthocyanin. The purpose of this study was to analyze the effect of blanching on color and the amount of anthocyanin of dried slice purple sweet potato. The blanching method studied was steam blanching with a temperature of 70oC-80 oC and blanch with boiling water 90 oC – 98 oC for 2 minutes. To measure the amount of anthocyanin by the pH difference method and measure color using the chromameter tool. The results showed that the steam blanching technique produced a higher color and amount of anthocyanin of dried chips purple sweet potato compared to blanching boiling water. This is because Anthocyanin dissolves in water. The conclusion is to get the color and the relatively high amount of anthocyanin in dried pieces of purple sweet potato can be done by steam blanching.

Keywords
Anthocyanin; blanching; Ipomoea batatas; purple sweet potato

Topic
Chemistry

Link: https://ifory.id/abstract/ugCcWeaQTA4t

Corresponding Author
Cahyo Puji Asmoro

Institutions
Universitas Pendidikan Indonesia

Abstract
This study was conducted to determine the effect of Ipomoea batatas L. leaf extract as flocculants on the reduction of Ca2 + and Mg2 + (hardness) levels in water treatment for chemical practicum on environmental analysis at the FPMIPA UPI Chemical Department. This study continued from previous research on the optimization of Ipomoea batatas L. leaf extract as a flocculant in water treatment, the results of the study showed that Ipomoea batatas L. leaf extract can make water clearer and provide greater reduction in turbidity value. In this follow-up study it will be carried out through two stages, the first step is optimizing the optimum processing parameters. The second stage is water treatment using optimum processing parameters, followed by hardness testing in water samples before and after processing. In hardness testing the EDTA titration method is used with the EBT indicator. The results showed the optimum parameters of water treatment with Ipomoea batatas L leaf extract as flocculant was pH 6.5, coagulant dose 50 mg / L, flocculant dose 2 mg / L, stirring coagulant speed 200 rpm for 5 minutes, and flocculant stirring speed 40 rpm for 5 minutes. In testing the total hardness as CaCO3, the initial sample (without treatment) obtained hardness of 285 mg / L, whereas in the sample treated with Ipomoea batatas L. leaf extract as flocculant hardness was obtained at 190 mg / L. From the results of the study it can be concluded that Ipomoea batatas L. leaf extract as flocculant in water treatment can reduce the hardness level in water.

Keywords
Biofloculan, Ipomoea batatas L., EDTA titration, Hardness.

Topic
Chemistry

Link: https://ifory.id/abstract/uqPLVtkhbNKF

Corresponding Author
Heli Siti Halimatul Munawaroh

Institutions
UPI

Abstract
Chlorella vulgaris and Navicula salinicola have been reported to have high lipid content and are potential to be used as an alternative source of bioenergy precursor compounds. However, to obtain a high biomass and lipid with autotropic cultivation condition is still a challenge therefore other cultivation condition such as photoheterotropic need to be explored. In addition, the influence of cultivation conditions on the production of biomass and lipid for diatomic microalgae, especially Navicula salinicola, is still rare explored. This study aims to analyze the effect of organic carbon sources namely sugarcane addition on the production of biomass and lipid of Chlorella vulgaris and Navicula salinicola. Analysis of biomass concentrations is evaluated by measuring dry cell weight (DCW), while lipid concentrations is evaluated by measuring total lipid levels from the extraction results using the Folch method. Lipid concentrations is calculated based on total lipid levels and biomass concentration obtained. The profile of fatty acid methyl ester (FAME) is analysed by using GC-MS. Based on the results of this study, it was observed that addition of sugarcane as an organic carbon source has increased the biomass production in Chlorella vulgaris and Navicula salinicola by 50.10% and 69.40% respectively than those are cultivated without the addition of sugarcane. Similarly, the addition of sugarcane has been showed to induced lipid accumulation in Chlorella vulgaris and Navicula salinicola by 34,45% and 25,51% respectively compared to those are cultivated with carbon source from the air. On the other hand, the addition of sugarcane as an organic carbon has decreased the variations of fatty acid in Chlorella vulgaris and Navicula salinicola by 3 and 4 types respectively than those are cultivated without the addition of sugarcane. The addition of sugarcane can suppress the variations of fatty acids in Chlorella vulgaris and Navicula salinicola but it stimulates the synthesis of palmitic acid (C16:0) which has potential to be applied to the biodiesel industry.

Keywords
Biomass, Chlorella vulgaris, Lipid, Navicula salinicola, Photoheterotropic

Topic
Chemistry

Link: https://ifory.id/abstract/MUJgEXdnT2L7

Corresponding Author
Muhammad Yudhistira Azis

Institutions

1Analytical Chemistry Research Group, Institut Teknologi Bandung,
Jl. Ganesa 10 Bandung 40132 Indonesia
2Chemical Engineering Product Design and Development Research Group
Institut Teknologi Bandung, Jl. Ganesha 10 Bandung, 40132 Indonesia

Abstract
Water contamination caused by dye industries, has caused more and more attention, since most dyes are harmful to human being and environments. Some dyes like methylene blue (MB) and their degradation products have carcinogens and toxic properties so that the removal of dyes from surface water or wastewater is very important. Physical adsorption using solid adsorbents has been a promising method for treating dyes, pigments and other colorant wastewater, owing to its advantages such as operational simplicity, low cost, availability in large amount and ability to treat pollutants in a sufficiently large scale operation. In this study, the sorption of MB from aqueous solution onto composite nanofiber under the influence of temperature has been investigated. It was observed that the amount of MB adsorbed increase with increasing temperature. Thermodynamic parameters data indicated that the MB adsorption process was non-spontaneous and endothermic under the experimental conditions, with the Gibbs free energy (?Go) in the range of 1.721-0.610 kJ mol-1, enthalpy (?Ho) and entropy (?So) of 7.24 kJ mol-1 and 18.52 J mol-1.K-1, respectively and the activation energy was 13.85 kJ mol-1.

Keywords
Effect of Temperature on Sorption of MB from Aqueous Solution using Composite Nanofiber

Topic
Chemistry

Link: https://ifory.id/abstract/A6GjpdNDzCwB

Corresponding Author
Riza Apriani

Institutions
a) Chemistry, Faculty of Mathematics and Natural Science, Universitas Garut
Jalan Jati No. 48B, Garut 44151, Indonesia
*aprianiriza[at]uniga.ac.id
b) Chemistry Department, Faculty of Mathematics and Natural Science, Universitas Padjadjaran
Jalan Raya Bandung-Sumedang Km. 21, Jatinangor 45363, Indonesia

Abstract
Cancer is a frightful disease and represents one of the biggest health-care issues for the human race and demands a proactive strategy for cure. Exploration of natural product containing anticancer agent provide a promising line for research on cancer. Moringa plant (Moringa oleifera) is one of the medicinal plants used in traditional medicine for the treatment of cancer. Several studies have reported that water and alcoholic leaves extracts of M. oleifera have anticancer activity in some cancer cell line, including HepG2 liver cancer cells, A549 lung cancer cells, Caco-2 colon cancer cells and MDA-MB-231 breast cancer cells, but study on T47D breast cancer cells has not reported yet. Therefore, this study was carried out to investigate the cytotoxic activity of ethyl acetat fraction of M. oleifera (EMO) on T47D cells by observing cell cycle profile. Cytotoxic activity was determined by MTT assay. Cell cycle analysis was performed using flow cytometry and cyclin D1 expression was analyzed using immunocytochemistry method. Based on preliminary MTT assay, T47D treated with EMO demonstrated a medium cytotoxic effect with an IC50 value of 135.312 ug/mL. Further assay indicated that EMO induced cell cycle arrest on G0/G1 phases. Immunocytochemistry assay showed that the EMO decreased expression of cyclin D1.

Keywords
Breast cancer, cell cycle, Moringa oleifera, T47D cell

Topic
Chemistry

Link: https://ifory.id/abstract/pfzYrkdue7XP

Corresponding Author
Dyah Fitriani

Institutions
*Chemistry Department, Faculty of Mathematics and Natural Sciences Universitas Bengkulu, Jl. WR Supratman, Bengkulu 38122, Indonesia

Abstract
A research on the extraction of essential oil from the peel and residue of squeezed kalamansi orange water has been carried out. This research aims to determine the yield resulting from the extraction of essential oil from the peel and residue of squeezed kalamansi orange water.Then,the quality of essential oil produced will be determined including specific gravity, refractive index as well as identification of the components of chemical compounds contained in essential oil by using GC-MS.The extraction of essential oil was done by steam distillation and water distillation. The comparison between samples and aquades was 1:1 and 2:1 either for the peel sample or the sample of residue of squeezed kalamansi orange water.From the results of extraction,the essential oil which was clearly colorless yellowish with a distinctive odor of kalamansi orange was obtained.The yield of essential oil produced from the residue squeezed kalamansi orange water at a ratio of 1:1 and 2:1 respectively was 1.34 % and 1.4 %, while that from the peel with a ratio of 1:1 and 2:1 respectively was 0.0294 % and 0.0258 %.The result of characterization using GC-MS showed the main component of essential oil was limonene with a content of 98% either from the peel or from the residue of squeezed kalamansi orange water. While, the specific gravity obtained ranged between 0.824 – 0.838 g/mL and the refractive index ranged between 1.4758 – 1.4765.

Keywords
Kalamansi Orange, Essential oil, GC-MS

Topic
Chemistry

Link: https://ifory.id/abstract/Etajm9G2U3wf

Corresponding Author
Neneng Windayani

Institutions
Department of Chemistry Education, UIN Sunan Gunung Djati Bandung
Jl. A. H. Nasution No. 105, Bandung 40614, Indonesia

a)E-mail: nenengwinda.ftk[at]uinsgd.ac.id

Abstract
This study aims to make facial wash gel made from Aloe vera L. as a natural surfactant. The experimental method used included the stages of analysis of Aloe vera extract samples, addition of carbomer 960 with a percentage of 0.5%, 0.7% and 2%, selection of essential oils according to facial skin requirements, testing of secondary metabolites contained in Aloe vera extract. Furthermore, making aloe gel as a facial wash by utilizing the secondary metabolites contained in Aloe vera that have characteristics in accordance with the Indonesian national standard (SNI). The results showed that Aloe vera extract used positively contained flavonoid, triterpenoid, saponin, and polyphenol compounds. It has been successfully made the best facial wash gel with formulation obtained in addition of carbomer 960 with a percentage of 0.7%. The organoleptic results of Aloe vera gel as facial wash include having an aroma in accordance with the added essence, soft texture, gel form, cloudy white color, feeling cool or cold when applied to facial skin, without foam and having a pH of 5.

Keywords
Aloe vera gel, facial cleanser, natural surfactant, secondary metabolite

Topic
Chemistry

Link: https://ifory.id/abstract/q8j3Nm2LRxa4

Corresponding Author
Intan Delia Sapitri

Institutions
Departement of Chemistry, Faculty of Mathematics and Natural Sciences, University of Bengkulu
Jl. W.R. Supratman, Kandang Limun 38317 A Bengkulu, Indonesia
*e-mail address : asdim[at]unib.ac.id, intandeliajg[at]gmail.com

Abstract
Tin (IV) dioxide (SnO2) is a semiconductor material with a band gap of around 3.6 eV. It is considerable technological importance with a number of applications, especially for photoelectrodes, detection of flammable toxic gases, thin film coatings, and gas sensors. This research aims to determine the effect of variations in glucose concentration as a capping agent to the crystallinity and morphology of SnO2. The synthesis of SnO2 nanoparticles has been investigated by using several methods such as hydrothermal, sol-gel and solvhotermal methods. Especially for hydrothermal method, several capping agents such as rarasaponin in Sapindus rarak, cetyl trimethylammonium bromide (CTAB), and ethylenediaminetetraacetid acid (EDTA) that can reduce the formation of aggregates. This synthesis was carried out by the hydrothermal method at 100 oC for 3 hours. SnO2 nanoparticles as synthesized was characterized by using X-Ray Difraction (XRD) and Scanning Electron Microscope (SEM). The crystallinity of SnO2 nanocrystal as shown in XRD pattern was influence by changing of glucose concentration. SEM images show that aggregate formation is influenced by variations of glucose concentration as a capping agent. These results show that aggregate growth in the formation of SnO2 nanoparticles could be controlled by optimized glucose concentration in reaction solution.

Keywords
Nanoparticles, SnO2, Capping agent, Glucose

Topic
Chemistry

Link: https://ifory.id/abstract/AMnZKwjRT9zG

Corresponding Author
M. Lutfi Firdaus

Institutions
1 Graduate School of Science Education, Bengkulu 38371, Indonesia
2 Material Science Research Group, Universitas BSI, Bandung 40291, Indonesia

Abstract
Here we report the green synthesis of silver nanoparticles using a reductant of fruit extract of common grape vine (Vitis vinivera), and its application for mercury ion detection. The precursor of silver nanoparticles was silver nitrate, and the formation of silver nanoparticles was accelerated in the presence of sunlight. After 30 minutes of sunlight irradiation, the yellowish-brown silver nanoparticles were formed with peak absorbance at 420 nm wavelength. The formed silver nanoparticles were then tested to various alkaline, alkaline earth and transition metals. Most of the metals has no effect to the silver nanoparticles except for mercury ions that change the color of silver nanoparticles to colorless. Therefore, silver nanoparticles are selective to detect mercury ions in aqueous solution. In addition, we used the digital image-based colorimetry method to quantify mercury ions in samples solution. Compared to the reference method, the developed colorimetry was accurate up to 99.38%.

Keywords
mercury; silver nanoparticles; vitis vinivera; colorimetry; spectrophotometry; digital image.

Topic
Chemistry

Link: https://ifory.id/abstract/7ACHzwnaeMD4

Corresponding Author
Pri Iswati Utami

Institutions
a) Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto
Jalan Raya Dukuhwaluh, Kembaran, Purwokerto, Indonesia
*asmiyentidjaliasrindjalil[at]ump.ac.id

Abstract
Adulteration of synthetic pharmaceutical drugs in jamu is prohibited by law in Indonesia. Glibenclamide is one of the drugs commonly added to jamu. The purpose of this study was to obtain a valid high performance liquid chromatography (HPLC) method for qualitative and quantitative analysis of glibenclamide in antidiabetic jamu. HPLC separation was carried out with a Kromasil 100 C18 column (150 x 4.6 mm i.d, 5 μm particle size) using methanol: water (75:25) v/v as the mobile phase at a flow rate of 0.5 mL/min, UV detection was set at 301 nm. There was no potential interference from other compounds at the glibenclamide retention time (retention time of 5.10 minutes). The method has good linearity (r = 0.9936) in the range 10-50 mcg/mL. The detection limit of the method was 6.21 mcg/mL while the quantitation limit was 20,71 mcg/mL. The relative standard deviation (RSD) of intraday precision was 1.923%. The average recovery using standard addition method was 100.65 ± 16.89%. The application of the HPLC method for the analysis of five antidiabetic jamu samples obtained from the market in Purwokerto showed that glibenclamide was detected in one sample with a level of 1.88 ± 0.25 mcg/g.

Keywords
antidiabetic jamu, glibenclamide, HPLC, validation

Topic
Chemistry

Link: https://ifory.id/abstract/dHXUBpAxn3VL

Corresponding Author
fajar fauzi abdullah

Institutions
a. Departement of Chemistry, Universitas Garut, Jl. Raya Samarang No.52A Garut, Indonesia.
*fajarfauzi[at]uniga.ac.id
b. Sultan Idris University of Education, Faculty of Mathematics and Sciences, Department of Chemistry, 35900 tg. Malim, perak, Malaysia.

Abstract
Objective: This study was to determine the antioxidant activity of marker compounds contained in Kaempferia galanga L. n-hexane extract, by isolating compounds from Kaempferia galanga L. n-hexane extract and examining antioxidant activity. Method: Kaempferia galanga L. dry powder was macerated with n-hexane for 3x24 hours. n-hexane extract was obtained and evaporated until the solution became 30mL then let it sit on the icebath, the residue obtained was then recrystallized with ethanol. The colorless crystalline solids obtained were then tested for antioxidant activity with the DPPH (1,1-diphenyl-2-pikrilhidrazil) method. Results: Spectroscopic analysis including UV Vis, IR, 1D-NMR and 2D-NMR showed that isolates were phenylpropanoid type compounds derived from hydroxycinamic acid in the form of ethyl-p-methoxy-cinnamic and strong intensity antioxidant activity indicated by IC50 value of 58,851 ppm. The benefits of this study can provide a basic knowledge of the utilization of the potential content of the main compounds from Kaempferia galanga L. for the pharmaceutical preparation field.

Keywords
Kaempferia galanga; Antioxidant Activity; Isolation secondary metabolites; ethyl-p-methoxy-cinnamate

Topic
Chemistry

Link: https://ifory.id/abstract/6yZDWe8zpUkx

Corresponding Author
Neneng Siti Silfi Ambarwati

Institutions
1Cosmetology Department, Faculty of Engineering, Universitas Negeri Jakarta, Jl. Rawamangun Muka, East Jakarta 13220, Indonesia.
2Faculty of Pharmacy, Universitas Indonesia, UI Depok Campus, Depok 16424, Indonesia.
3Research Center for Chemistry, Indonesian Institute of Sciences (LIPI), Kawasan PUSPIPTEK, Serpong, Tangerang, 15314, Indonesia.
4Faculty of Pharmacy, University of Pancasila, Srengseng Sawah, Jakarta, Indonesia.
5Chemistry Division, Centre for Foundation Studies in Science, University of Malaya

Abstract
Background. Garcinia latissima Miq. (Clusiaceae) grows on the island of Seram Maluku and Papua, but was cultivated in the Bogor Botanical Garden since May 11th 1994. Previous research has been done that ethyl acetate extract of G. latissima Miq. leaves with 2% concentration in dimethyl sulfoxide against Bacillus subtilis used agar diffusion method gave inhibition zone diameter 7.68 mm. The minimum inhibitory concentration (MIC) of the extract against B. subtilis was 5,000 ppm and the minimum bactericidal concentration (MBC) was 10,000 ppm. Purpose. The purpose of the study was to get isolate from G. latissima Miq. leaves ethyl acetate extract and to understand its activity against B. subtilis. Methods. The isolation was performed by open column chromatography, recrystallization, preparative thin layer chromatography and the isolate antibacterial assay by microdilution method. Spectroscopic characterization using ultra violet spectroscopy (UV-Vis), infra red spectroscopy (FTIR), 1H-NMR, 13C-NMR, DEPT, HSQC. Result. The isolated compound was white crystal, soluble in chloroform and insoluble in n-hexane, ethyl acetate. The melting point of the isolated compound was 262-264oC. IR spectrum showed strong signals for C-H stretching of methyl groups and carbonyloxygen (C=O). The based on NMR data, the chemical shifts of chemical compounds from the isolate was compared with the literature showed that the isolate was friedelin. The MIC of friedelin against B. subtilis was 2,500 ppm.

Keywords
Garcinia latissima Miq., isolation, characterization, antibacterial, Bacillus subtilis

Topic
Chemistry

Link: https://ifory.id/abstract/qxWBJfVc6bYt

Corresponding Author
Ella Fitriani

Institutions
Universitas Negeri Jakarta, Chemistry Education Department, Faculty of Mathematics and Natural Sciences, Jalan Rawamangun Muka 13220, Jakarta, Indonesia

Abstract
The chemical bond is one of the crucial topics in chemistry since it becomes a basic concept to comprehend other topics. Unfortunately, it is hard for students because it is at the microscopic level. This study proposes a way to comprehend that topic by developing a simulation of 3D molecules using Augmented Reality (AR). The data were collected by questionnaire, documentation, and interview. This study was used ADDIE procedure to develop the product. From the results of this study, it can be concluded that the multimedia-based learning media Augmented Reality has very good quality and is worthy of being used as a supporting media in chemical learning activities in the chemical bond topic.

Keywords
Augmented Reality, Chemical bond, 3D molecules, ADDIE

Topic
Chemistry

Link: https://ifory.id/abstract/nBA4vjyfGC3P

Corresponding Author
Yulia Sukmawardani

Institutions
Prodi Pendidikan Kimia, Fakultas Tarbiyah dan Keguruan UIN Sunan Gunung Djati Bandung

Abstract
This research is based on the needs for an innovative experimental learning media in the study of physical chemistry, focus on conductivity of electrolyte solutions. Through Research and Development with the stages of analysis, design and development, the electrolyte solution conductivity meter has been produced. Based on the results of the research, it was obtained the product in the form of an electrolyte solution conductivity measuring instrument equipped with a user guide to the use of an electrolyte solution conductivity measuring instrument and an experimental worksheet measuring the conductivity of an electrolyte solution. The electrolyte solution conductivity meter is designed to measure the conductivity of an electrolyte solution and can compare the conductivity values of fruit juices, vegetable juices and isotonic drinks quantitatively based on Kohlrauschs law with simple and easy tools and materials to obtain. Validation results indicate that the product is declared valid with the acquisition of an average value of R is 0.83. The results of the feasibility tests conducted on chemistry education students show that the electrolyte solution conductivity gauge is declared very feasible with an average value of 93.85%.

Keywords
Conductivity, electrolyte solutions,chemistry learning media , physical chemistry

Topic
Chemistry

Link: https://ifory.id/abstract/KHBdutYjy9z7

Corresponding Author
Abigail Parcasio Cid-Andres

Institutions
Department of Physical Sciences, College of Science, Polytechnic University of the Philippines, Anonas St., Sta. Mesa, Manila 1016

Abstract
The contamination of water sources by pathogenic bacteria poses a threat both in the environment and in human health. The incorporation of metal nanoparticles in polymer matrix which is abundantly available in a country can be improved to enhance its antimicrobial property. This study was focused on the development of a novel antibacterial water filter from synthesized silver-copper nanoparticles (Ag-CuNPs) incorporated into Philippine abaca fiber (Manila Hemp). Pre-treatment method and determination of adsorption capacity of abaca fiber towards metal ions, Ag+ and Cu2+ were done prior to synthesis of Ag, Cu and Ag-Cu nanocomposites. Alkali treatment of the fiber confirms OH, C-O and C=O of a cellulose, pectin and lignin in the FTIR analysis. These groups effectively altered the nature of the abaca fiber to hydrophobic, thus, increasing its adsorption capacity up to 80%. Morphological and structural properties of the formed nanoparticles were confirmed using scanning electron microscopy (SEM) revealing polymeric matrices of the fiber in the particle size of 80 nm – 100nm. UV-Vis spectra revealed a broadening of the absorption spectra of a bimetallic Ag-Cu nanoparticles at 410 nm. The antimicrobial assay results revealed promising synergism of the combined silver and copper nanoparticles against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacterial strains in synthetically prepared water. Also, a relatively proximate bactericidal efficiency was attained between the CuNPs and Ag-CuNPs abaca fiber composites. The developed Ag-CuNPs abaca fiber composite can act as novel antibacterial water filter for water disinfection.

Keywords
Water disinfectant, Metal Nanoparticle, Antimicrobial Property, Polymer Matrix

Topic
Chemistry

Link: https://ifory.id/abstract/9JZhzPVFGvkg

Corresponding Author
Willy Cahya Nugraha

Institutions
(a,b) Research Unit for Clean Technology,
Indonesian Institute of Sciences
Jl. Cisitu Sangkuriang, Bandung 40135
Telp/Fax : (022) 2503051/(022) 2503240
*E-mail : will003[at]lipi.go.id

Abstract
Nitrate is one of pollutants which is found in water and dangerous for human health. Spectrophotometer UV Vis method using cadmium reduction is a simple method and cheap but it has a difficult technique and can be used for nitrate analysis. The method was validate according with analytical parameters. The result of this study were linear range 0.069- 5 mg.L- 1, limit detection and quantitation were 0.025 mg.L-1 and 0.069 mg.L-1, respectively. repeatibility of the method 2.19 % rsd and accuracy with 102.7 % recovery. All of parameters have a good performance and can be used for nitrate analysis for water sample.

Keywords
water, nitrate, spektofotometer UV Visible, validate

Topic
Chemistry

Link: https://ifory.id/abstract/3QgPpzLyjuAY

Corresponding Author
Henry Setiyanto

Institutions
1Analytical Chemistry Research Group, Institut Teknologi Bandung, Bandung, Indonesia
2Research Unit for Clean Technology, Indonesian Institute of Sciences, Bandung, Indonesia
3Department of Physics, Universitas Negeri Malang, Malang, Indonesia

Abstract
Phenol is an aromatic derivative of hydrocarbons from coal which used as a base for making plastic bottles, cans of packaged food, cosmetics, and pesticides. A large amount of phenol in industrial fields cause phenol easily found in water. However, this compound is emerging as a pollutant in the environment and cause harm to animals. Phenol is also known to be highly reactive to human body tissue if absorbed through skin, breathing, and digestion. In this work, carbon paste electrode based on Ag nanoparticle was developed for the detection of phenol. Carbon paste electrode was modified with Ag nanoparticles which were previously synthesized first and then mixed with graphite and paraffin. The best composition of CPE-nAg is 5:70:25 for Ag nanoparticles, graphite, and paraffin. After measurement using CPE-nAg, it is necessary to remove phenol on the electrode surface with 6 cyclic. Measurement was carried out using square wave voltammetry techniques in the potential range of 0 V to 1,2 V, frequency of 10 Hz, and a scan rate of 75 mV/s. The result showed the presence of an oxidation peak of phenol is 0,475 V in sodium hydroxide 1 M solution.

Keywords
CPE, Ag nanoparticles, voltammetric, phenol

Topic
Chemistry

Link: https://ifory.id/abstract/eNtUbAXZ7C49

Corresponding Author
Henry Setiyanto

Institutions
1Analytical Chemistry Research Group, Institut Teknologi Bandung, Bandung, Indonesia
2Research Unit for Clean Technology, Indonesian Institute of Sciences, Bandung, Indonesia
3Department of Physics, Universitas Negeri Malang, Malang, Indonesia

Abstract
The modification of carbon paste electrode (CPE) with molecularly imprinted polymer (MIP) for determination of rhodamine-B by potentiometry method has been studied. The experiments were performed using glutamic acid as a monomer. The composition of monomers, the number of electropolymerization cycles and pH of the solution were used to describe modification electrodes made (CPE-MIP-s) and the electrode characteristics were evaluated. It was observed the amount of oxidation current signal increase with increasing glutamic acid concentration. The optimal polymerization molar ratio of the functional monomer to the template molecule rhodamine-B was 3:1; the maximum number of electropolymerization was 15 and the optimum pH of supporting electrolyte solution was 4.

Keywords
CPE, MIP, polyglutamic acid, rhodamine-B

Topic
Chemistry

Link: https://ifory.id/abstract/dMyG4hzwZVr7

Corresponding Author
Neena Zakia

Institutions
a) Division of Analytical Chemistry, Institut Teknologi Bandung
Jalan Ganesha 10, Bandung 40132, Indonesia
*neena.zakia.fmipa[at]um.ac.id
b) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang
Jalan Semarang 5, Malang 65145, Indonesia

Abstract
Alpha mangostin is a major component in the mangosteen rind, which has activity as an antioxidant, antitumor, hypo-allergenic, and anticancer. The aim of this study is to synthesize molecularly imprinted polymer (MIP) for alpha mangostin adsorption. The MIP was prepared by bulk polymerization with alpha mangostin as template, methacrylic acid as the monomer, ethylene glycol dimethacrylate as the crosslinker, and benzoyl peroxide as the initiator and acetonitrile as porogenic solvent. A molar ratio of template:monomer:crosslinker is 5:4:20. A non-imprinted polymer was synthesized in the absence of alpha mangostin. Solvent extraction is carried out to remove the template used methanol:acetic acid (90:10, %v/v) as the solvent. The surface morphology of MIP was visualized by scanning electron microscopy (SEM). The synthesized MIP was characterized by infra red spectroscopy. It showed that wavelength number were 2957, 1603, and 1456 cm-1 assigned to characteristic vibration of a C-H bond, a chelated carbonyl group and a methoxy groups, respectively, which indicated the present of template molecule. The adsorption capacity of MIP for alpha mangostin was 12,17 mg/g with the imprinting factor 1,2. Overall, this MIP has a good chance to be used as functional material for alpha mangostin adsorption.

Keywords
alpha mangostin, molecularly imprinted polymer, adsorption

Topic
Chemistry

Link: https://ifory.id/abstract/UdctrnqCDYgE

Corresponding Author
Agus Sundaryono

Institutions
1Graduate School of Science Education, University of Bengkulu, Bengkulu Indonesia
2 Undergraduate School of Chemistry Educations, University of Bengkulu, Bengkulu

Abstract
Kebiul seeds (Caesalpinia bonduc) are seeds from the Kebiul plant that are widely used by the serawai tribe in Bengkulu Indonesian as malaria medicine. The purpose of this study was to scientifically prove the efficacy of Kebiul seeds as an anti-malaria medicine preclinically in mice by measuring percent (%) chemosuppresion of crude extract of Kebiul seeds. Twenty-five mice were divided into 5 groups, K-, K +, P1, P2 and P3 each group were infected with Palsmodium berghei, three days after infection, the number of parasitemia that infected eritrocytes of mice was calculated, if the number of parasites had reached 20-30%, then mice were treated orally for 3 days according to their group. Group (K-) treated with olive oil, group (K +) with chloroquine, and groups P1, P2 and P3 were treated with crude extract of Kebiul seeds at a dose of 0.028 g / kgbw; 0.056 g / kgbw and 0.084g / kgbw. The average number of parasitemia developments is calculated from the first day of treatment to up to 7 days. The average percent (%) chemosuppresion in the administration of crude extract Kebiul seeds at a dose of 0.028 g / kgbw was 51.21% higher than the administration of chloroquine (50.77%). Based on this result, Kebiul seed extract at a dose of 0.028 g / kgbw can be developed as a new traditional medicine as a substitute for anti-malaria medicine chloroquine, because it has been reported in several areas including Bengkulu that malaria is resistant to chloroquine.

Keywords
Biji Kebiul (Caesalpinia bonduc); Anti malaria; Klorokuin; Traditional medicine; Palsmodium berghei

Topic
Chemistry

Link: https://ifory.id/abstract/xwJaYVvz7FtU

Corresponding Author
Mirsa Umiyati

Institutions
Universitas warmadewa

Abstract
ABSTRACK Coconut pulp is a waste food ingredient from the manufacture of coconut oil and VCO. The disadvantage of feed ingredients derived from waste is the low quality of the feed ingredients. Therefore, it is necessary to do processing technology, namely fermentation which is useful to improve the quality, digestibility and shelf life of these feed ingredients. The research was divided into two stages, namely 1) collecting coconut pulp, drying it, pressing it and then fermenting the coconut pulp produced. 2) Research on the maintenance of super female native chickens whose purpose is to prepare hens as producers of native chicken eggs. The research was carried out at the Basic Laboratory of the Faculty of Agriculture, Warmadewa University with a level of use of fermented coconut pulp, namely R0 (ration that contains no fermented coconut pulp, R1 (ration containing 5% fermented coconut pulp flour), R2 (ration containing 10 % fermented coconut pulp) and R3 (rations containing 15% fermented coconut pulp). Each combination of treatments was repeated three (3) times, and each replication consisted of 4 super female native chickens. Variables observed included: 1 ). Age of chicken growth includes the weight gain and final weight of super native chicken, 2) Percentage of carcass and non carcasses for super native chicken, 3) Feed Convertion Ratio (FCR, 4) Feed consumption, and 5) B / C ratio. From this study it was found that the giving of coconut pulp flour was fermented up to 10% (R2) significantly (P <0.05) could increase weight gain and final weight and B / C ratio of 14 weeks super female native chicken, and flour dregs fermented coconut to the level of 10% also decreases ration consumption and the conversion of ration for super female chicken 14 weeks old. Thus for the maintenance of super female native chickens it is recommended to provide fermented coconut pulp flour up to the level of 10%

Keywords
Performance, Carcass, Super Native Chicken, Coconut Dregs, Fermentation

Topic
Chemistry

Link: https://ifory.id/abstract/rZjMCEQWxczq

Corresponding Author
Heli Siti Halimatul Munawaroh

Institutions
UPI

Abstract
Phycocyanin is the main pigment in Spirulina platensis which is reported has potential to be used as a natural inhibitor for α-amylase and α-glucosidase. The pigment can effectively treat type-2 diabetes mellitus by lowering blood glucose. However, molecular interactions between phycocyanin and the two enzymes are less studied. In this study, an in silico study through molecular docking simulation was carried out to predict the molecular interactions of phycocyanin and both of α-amylase and α-glucosidase. In vitro evaluation of phycocyanin as an anti-diabetic is determined through the inhibitory activity of phycocyanin against α-amylase derived from human saliva. Storage stability in three conditions was evaluated in its application as a functional supplement. Docking simulations between phycocyanin and acarbose as commercial drugs with α-amylase and α-glucosidase enzymes were performed using the AutoDock Tools program. Determination of inhibitory activity was carried out using the FUWA method, while the measurement of absorption values with a UV-Vis spectrophotometer. Storage stability study was performed on solid and solutions-stated of phycocyanin at three different conditions, namely dark conditions at -4°C, dark conditions at room temperature, and bright conditions at room temperature. The stability was determined by measuring the absorption values at λ620 and λ652 using UV-Vis spectrophotometer. Molecular docking simulations show that phycocyanin, inhibits by binding to the active site of the enzyme, causing disruption of the attachment of the substrate to the enzyme. The simulation indicates that phycocyanin has potency to be used as a candidate for anti-diabetic natural therapy agents. An in vitro inhibition activity test showed that phycocyanin inhibits α-amylase from human saliva at average 50.13%. Storage stability tests showed that the concentration of phycocyanin in the form of solutions and solids, was stable for seven days of testing under conditions of dark storage and low temperatures.

Keywords
Diabetes mellitus type-2, Phycocyanin, Molecular Docking, Stability, α-amylase, α-glucosidase

Topic
Chemistry

Link: https://ifory.id/abstract/BjcEZ4LXnm8U

Corresponding Author
Dhini Annisa Rahmasari Kanto

Institutions
a) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Garut University
Jalan Jati No. 42B, Garut 44151, Indonesia
*dhini.annisakanto[at]gmail.com
b) Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Garut University
Jalan Jati No. 42B, Garut 44151, Indonesia

Abstract
Syzygium is a genus belongs to Myrtaceae. One species of the genus is cashew rose (Syzygium jambos (L.) Alston) which contains secondary metabolites, such as flavonoids, tannins, steroids/terpenoids, alkaloids and saponins. This study aimed to find the content of these secondary metabolites using thin layer chromatography (TLC) and its antioxidant activity. The simplicia of cashew rose leaves was extracted by maceration using methanol as a solvent for 64 hours. This results in methanolic extract of cashew rose leaves. The resulted chromatogram using n-hexane and ethyl acetate eluent showed that the methanolic extract of leaves cashew rose has at least five compounds with retention value (Rf) consecutively were 0.32, 0.36, 0.68, 0.72, and 0.84. The stains could be seen in UV light 356 nm, but not in UV light 254 nm. It can be concluded that these compounds were classified as nonfenolic compound. The antioxidant test of methanolic extract of cashew rose leaves showed a very strong antioxidant activity with IC50 value of 13,554 ug/mL.

Keywords
Syzygium jambos (L.) Alston; chromatogram; DPPH; antioxidant; IC50

Topic
Chemistry

Link: https://ifory.id/abstract/9YDbrgKQZhJF

Corresponding Author
Shendi Suryana

Institutions
Universitas Garut

Abstract
Rose Guava (Syzygium jambos (L.) Alston) is known to have flavonoid compounds. Where flavonoids are natural product compounds that have uses as a treatment. An alternative method used to determine the prediction of total flavonoid levels is a combination of FTIR and Chemometrics (Partial least square regression) through the parameter RMSEC value (Root mean square error of calibration), RMSECV (Root mean square error of validation), PRESS (Predicted residual error sum of squares) and R2. The results of the combination of FTIR and CEMOMETRICS (Partial least square regression) on the prediction of total flavonoid levels can provide a good model with calibration obtained R2 value 0.9999, RMSEC 0.0000637 and the results of vaid obtained PRESS value 0.19225, R2 0.978 and RMSECV 0.041 . Based on the literature, the model can be said to be good if the RMSEC and RMSECV values are smaller than R2.

Keywords
Flavonoid, Rose guava, Chemometri

Topic
Chemistry

Link: https://ifory.id/abstract/Fq98c6DQbxLv

Corresponding Author
Surya Lubis

Institutions
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala

Abstract
Modification of hematite (α-Fe2O3) with ZnO to produce ZnO/α-Fe2O3 composites by sol gel method and their photocatalytic activity testing on the degradation of indigo carmine (IC) dye has been done. The hematite was extracted from iron sand taken from Syiah Kuala Beach, Deah Raya, Aceh Province by using hydrochloride acid and co-presipitated by using ammonium hydroxide. The ZnO/α-Fe2O3 composites were prepared with the mol ratio of ZnO to α-Fe2O3 1:5, 5:1 and 1:1. The characterization by using X-Ray Difractions (XRD) and Scanning Electron Microscopy Energy Dispersive X-Ray Spectroscopy (SEM-EDS) was conducted in order to study the physical and chemical properties of the materials. The result of photocatalytic activity test showed that composites with the mol ratio of ZnO to α-Fe2O3 1:5 has the highest photocatalytic activity with the percent of degradation (% D) of IC are 91,67% and 93,18% under UV light and sunlight irradiation, respectively. These highest of photocatalytic activity was obtained at the initial pH of dye solution =1, photocatalyst dosage of 300 mg, initial dye concentration was 15 ppm and irradiation time 120 minutes under UV light and 90 minutes under sunlight.

Keywords
hematite; ZnO; indigo carmine: photocatalyst; sol gel

Topic
Chemistry

Link: https://ifory.id/abstract/MnqXHC7E2fmA

Corresponding Author
Fitri Khoerunnisa

Institutions
a) Department of Chemistry, Indonesia University of Education Bandung, Indonesia 40154
b) Clean Technology Research Division, Indonesian Institute of Science, Bandung, Indonesia, 40135
c) Department of Chemical Engineering, Bandung Institute of Technology, Bandung, Indonesia, 40116

Abstract
This study aims to prepare and to investigate the physicochemical properties of superabsorbent hydrogels (SH) based on poly (vinyl alcohol)/ poly (ethylene glycol) with an aid of glutaraldehyde crosslinker. The SH was synthesized using solution mixing method. The physicochemical properties of synthesized SH were determined by means of FTIR spectroscopy, X-ray diffraction, scanning electron microscopy, thermal gravimetric analysis, tensile strength, swelling ratio, and water retention tests. The results revealed that the optimum volume ratio of PVA (2.5% w/v): PEG (2.5% w/v): GA (3.33x10-5 % v/v) composition on SH was 2:3:3. The predominant interaction between polymer precursors involved functional moieties of C–O/C–O–C, C=O, C–H and –OH via hydrogen bonding. Copolymerization with PEG was not only modified crystallinity, tensile strength, thermal stability, and elasticity but also improved porous structure of PVA. The synthesized SH has huge water absorption capacity with water swelling ratio (% SR) and water retention (% WR) of 1230% and 53%, respectively.

Keywords
Superabsorbent; hydrogel; PVA; PEG

Topic
Chemistry

Link: https://ifory.id/abstract/xNUap2jWQeYw

Corresponding Author
NURUL FAUZIAH

Institutions
a) Postgraduated student of Science Education, University of Mataram. Jalan Majapahit No. 62, Lombok, Indonesia
*imnurulfz[at]gmail.com
b) Science Education, Postgraduated Program, University of Mataram. Jalan Majapahit No. 62, Lombok, Indonesia

Abstract
Chemistry learning should be able to facilitate students to have 21st century competencies and skills and also conservative attitude towards the environment. However, in its implementation was encountered obstacles, one of which is the problem of representative learning devices. The aims of study to produce and discover the quality of problem-based learning devices oriented to green chemistry in the reaction rate concept. Learning device consists of syllabus, lesson plan, student worksheet, modules, and test instruments. This research and development adapted Nieveens model which consisted of four stages: preliminary research, prototyping stage, summative evaluation, and reflection and documentation. The quality of the learning devices developed was measured through analysis of validity and practicality. Product validity assessment used validation questionnaires distributed to experts, the data obtained were analyzed by using the content validity formula. Practicality used response questionnaires assessed by teachers and students, and implementation of learning was analyzed by using a percentage of practicality. This study resulted in the average of content validity being 0,67 categorized valid. The practicality percentage of each espect is 90,87%, 80,06%, and 80,56% catogorized highly practical. The concluded that learning devices developed fulfills the criteria for developing quality products that are valid and practical.

Keywords
Learning devices, problem-based, green chemistry, reaction rate concept.

Topic
Chemistry

Link: https://ifory.id/abstract/YrDwdCmM3ub2