Indonesia Conference Directory

Corresponding Author
Sugiatmi Sugiatmi

Institutions
1 Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta
sugiatmi[at]umj.ac.id
2 Faculty of Public Health, Universitas Muhammadiyah Jakarta

Abstract
Background Prevalence of hypertension in adolescents increases. There are only few studies of hypertension prevalence and its association with fast food consumption and physical activity in Indonesian adolescent. Objective This study determine the blood pressure status and its association with fast food consumption and physical activity in adolescent Method. This cross sectional study was conducted during January and August 2018 in Senior High School in South Tangerang, Indonesia. 220 students were selected by proportional stratified random sampling. Blood pressure measurements were categorized as normal, prehypertension, or hypertension using the 2004 Fourth Report blood pressure screening recommendations. Fast food consumption was collected using Food Frequency Questionnaire and divided into often and rare. Physical activity was categorized using Baecke questionnaire into active and not active. Associations between fast food consumption and physical activity with blood pressure were determined using Chi Square test. Results Prevalence of prehypertension was 11.5% and hypertension was 12.0%. Fast food consumption and physical activity were not associated with prehypertension/hypertension (p value > 0.05). Conclusion Hypertension and prehypertension were highly prevalent in the studied adolescent. There were no associations between fast food consumption and physical activities with adolescent blood pressure.

Keywords
Fast food, physical activity, hypertension, adolescent

Topic
Public Health and Occupational Health

Link: https://ifory.id/abstract/N7CUw3E8XzTg

Corresponding Author
Siti Annisa Devi Trusda

Institutions
a)Biochemistry Department, Faculty of Medicine, Universitas Islam Bandung
Tamansari 22, Bandung, Indonesia, trusda_75[at]yahoo.com
b) Public Health Department, Faculty of Medicine, Universitas Islam Bandung
c) Histology Department, Faculty of Medicine, Universitas Islam Bandung
d) Physiology Department, Faculty of Medicine, Universitas Islam Bandung

Abstract
Introduction: Liver cancer is the sixth most common cancer and also the third highest cause of death caused by cancer. Failure in default therapy, side effects, and expensive cancer therapy lead researchers to be encouraged to look for effective and selective new cancer therapies. The aim of this study were to explored the effect of flavonoid active compound from clove leaf oil on liver cancer cells and its combination with standard drug for cancer therapy. Method: The cytotoxicity of active compound isolated from clove leaf oil and standard drug were analyzed on liver cancer cell culture and examines by MTT assay. The drug combination synergisms were indicated by the combination index (CI) using CompuSyn 1.4. Result: The results showed that flavonoid active compound from clove leaf oil in combination standard drug have Combinations Index below 1. Conclusion: It was concluded that flavonoid active compound from clove leaf oil were shown to have anticancer activity on liver cells culture and also have synergistic effect in combination with standard drug for cancer therapy.

Keywords
clove leaf, combination index, cytotoxic activity, flavonoid, liver cancer

Topic
Biopharmaceutical Product and Engineering

Link: https://ifory.id/abstract/rgWfUdKwXTYk

Corresponding Author
Roselina Panghiyangani

Institutions
(1)Faculty of Medicine, (2)Master Program in Public Health, (3}Bachelor Program in Public Health, Faculty of Medicine, University of Lambung Mangkurat.
Corresponding author :
roselina.darma[at]gmail.com

Abstract
Fluor albus is a symptom very often experienced by most women. Fluor albus is classifie into two types, namely, physiological and pathological fluor albus. The pathological fluor albus is caused by infection or inflammation which can lead to many problems in the reproductive health of teenagers. The purpose of this study was to analyze the effectiveness of health education on the knowledge, attitude and motivation about vaginal hygiene and prevention of fluor albus in An-Najah Aliyah School female students. Research design was pre-experimental pretest and posttest one group design. The population of this study were 130 female students of An-Najah Aliyah School, from which a sample size of 64 female students were selected. Sampling was conducted with proportional stratified random sampling technique. The research data were analyzed with the Wilcoxon test. The results showed that there were significant differences in the knowledge, attitude and motivation of the female students between before and after being given health education about vaginal hygiene and prevention of fluor albus (p value < 0.05). The conclusion is that health education is effective in increasing the knowledge, attitude and motivation about vaginal hygiene and preventing fluor albus of female students in Aliyah An-Najah School.

Keywords
fluor albus, reproductive health, knowledge, attitude, motivation

Topic
Public Health and Occupational Health

Link: https://ifory.id/abstract/dvcUbatJLw8z

Corresponding Author
Agung Firmansyah Sumantri

Institutions
Fakultas Kedokteran Universitas Islam Bandung

Abstract
Tyrosine Kinase Inhibitor is still the main therapy in Chronic Myeloid Leukemia (CML) but some cases showed a high degree of resistance to TKI due to autophagy mechanism in resistant stem cells. Chloroquine is a drug that has an anti-autophagy function. The aim of this study was to analyze the synergism of combination therapy of chloroquine and nilotinib in causing cell death in nilotinib-resistant CML and to compare the differences in the percentage of cell death in nilotinib-resistant CML between single nilotinib therapy and combination of nilotinib and chloroquine. The methode used in this study was in-vitro laboratory experimental test using peripheral mononuclear blood cells isolated from 4 nilotinib-resistant CML patients. The data was analyzed using CompuSyn software that identifiesd a combination index and one way ANOVA parametric test followed by post hoc test using tukey test. The result of the study based on combination index showed that combination of nilotinib and chloroquine had a synergistic effect in increasing nilotinib-resistant CML cell death whereas ANOVA showed significant differences between single-drug nilotinib vs combination of nilotinib and chloroquine (p<0,05). Based on the result of study, it can be concluded that the combination of nilotinib and chloroquine is synergistic in causing death to nilotinib-resistant CML cells and also increasing CML cell death compared to a single-drug of nilotinib.

Keywords
Chronic Myeloid Leukemia (CML), Tyrosin Kinase Inhibitor (TKI) resistant, chloroquine

Topic
Drug Discoveries and Development

Link: https://ifory.id/abstract/fzb9akXgYwUC

Corresponding Author
Nova Yuliati

Institutions
Communication Post Graduate Program,
Universitas Sebelas Maret
Solo, Indonesia.

Abstract
Abstract— Citizens Concern for Aids (WPA) is the first form of community action and participation to respond to HIV and Aids in Indonesia and is officially recognized by the National Aids Commission. WPA has the readiness, ability and willingness to participate in preventing and overcoming problems caused by medical illness due to behavior in this case Hiv-Aids along with other diseases that accompany themselves independently. The study was conducted at WPA in 4 (four) districts in the city of Bandung. The results of this study show participation local women as agent in community health. process of critical exploration of women cadres in concerning Hiv-Aids among community members, and communication model for resolving low health literacy risk related Hiv-Aids. Using a qualitative descriptive paradigm with the case study method, data were collected through in-depth interviews and documentation studies. Keywords—communication, young women, reproductive health

Keywords
Women empowerment, health literacy, community health, hiv-aids.

Topic
Community and Occupational Health

Link: https://ifory.id/abstract/aRQKVXbAFYJC

Corresponding Author
NABIL SAAD HARMAL

Institutions
a. Faculty of medicine, Asia Metropolitan University, Johor, Malaysia. *drnabil[at]amu.edu.my.
b. Medical microbiology, Faculty of medicine, Cyberjaya University College of Medical Sciences (CUCMS), Cyberjaya, Selangor, Malaysia.
c. National center of public health laboratories, Sana-a, Yemen.

Abstract
Introduction In Yemen, devastated by war, it has been reported that the cholera epidemic disease among the largest of cutting-edge times. The aim of this study is to describe the epidemiological features including the people at risk, drivers of cholera transmission and the drug resistance pattern of the aetiological agent in Sana-a- Yemen. Methods All the suspected cholera cases presenting at the medical health laboratory centre in Sana-a during the period from January to May 2019 were considered in this study. Epidemiological variables included in addition to the results of the rapid diagnostic methods and antimicrobial susceptibility. Bacterial cultures were carried out to confirm the diagnosis. Results The cumulative total number of suspected cholera cases from 1st January 2019 to 18th May 2019 is 49096, with 969 have been confirmed as cholera-positive for Vibrio cholerae O1 Ogawa strain by culture at the central public health laboratory in Sana-a and 49 associated deaths (CFR 0.10%). The highest death rate was among the elderly (>60y) represent 55% of total suspected cases. Among the clinical isolates 100 % resistance towards both; Nalidixic acid, Nitrofurantoin and 69% sulfamethoxazole/trimethoprim. The majority of the isolates (69%) showed multidrug resistant pattern towards four different antibiotics. Conclusion Our results suggested that the cholera epidemic in Amanat Al Asimah, Yemen is caused by multidrug resistance strains. Hence, the rapidly emerging multidrug resistance must be monitored closely and health authorities and partners should immediately enhance current control efforts to mitigate the risk of a new cholera epidemic wave in Yemen.

Keywords
Vibrio cholera; Ogawa; Cholera; epidemic; Yemen; resistance pattern.

Topic
Infectious and Non Infectious Diseases

Link: https://ifory.id/abstract/euZEW7GFPHT4

Corresponding Author
Shenny Dianathasari

Institutions
Anatomy Departement, Faculty of Medicine, Bandung Islamic University

Abstract
Sleep disorder breathing (SDB), especially obstructive sleep apnea syndrome (OSAS) is the most commonly found in stroke patients (more than 50). Numerous studies have shown the correlation between worsening of OSAS and several antrophometric measurement. These measurement are easy to obtain with no additional costs in patients suspected to have OSAS. The purpose of this study is to find out the correlation between athropometric measurement and the obstructive sleep apnea syndrome (OSAS) on patient with ischemic stroke. The method of this study was anthropomeric measurement including neck circumference, waist circumference and body mass index were assessed with cross-sectional design in 43 acute phase ischemic stroke patient with OSAS based on head CT-scan in RSAU dr. M. Salamun Bandung in August–December 2016. The result is no correlation was observed between neck circumference and waist circumference with OSAS. A statiscally significant correlation was found between BMI and OSA (p<0.05). Our study indicate that BMI is the major contributing factor to OSAS.

Keywords
anthropometri, ischemic stroke, OSAS

Topic
Basic and Clinical Medical Sciences

Link: https://ifory.id/abstract/q6UkNRgdynK2

Corresponding Author
ARIF WIDODO WIDODO

Institutions
Nursing Study Program – Health Science Faculty – Muhammadiyah University of Surakarta, Indonesia

Abstract
Foreword, Minimum service standards (MSS) in the health sector are a reference for district / city governments in providing health services entitled to be obtained at a minimum level by every citizen. Every person with a mental disorder (PwMD) has the right to get the minimum service according to the standard provided by doctors and nurses in the civil health center working area. The results of this study are; 1) the good commitment revealed by the head of the District Health Office by implementing some good policies in order to improve community mental health, but unfortunately they are still at limited common policies. 2) Minimum mental health service standards have not yet been carried out, 3) The implementation of health promotion involved families and the community. Conclusion: MSS mental health has not been done in accordance with the community expectations. The community expects that mental health services can be carried out at the nearest Civil Health Center. Suggestion: MSS mental health needs to bemore optimized by involving nurses, other health workers and the community.

Keywords
Minimum service standards, Mental health services, shackled

Topic
Public Health and Occupational Health

Link: https://ifory.id/abstract/VMGFAxDZHYE4

Corresponding Author
RISMALINDA RISMALINDA

Institutions
1 Lecturer in the Faculty of Industrial Engineering, Bhayangkara University, Jakarta Raya Bekasi City, West Java, Indonesia
2 Lecturer of Nursing Study Program III, STIKES Bani Saleh Bekasi City, West Java Indonesia
3 Lecture Of Nursing Study Program III, STIKES Majalengka, West Java Indonesia, West Java Indonesia

Abstract
This phenomenological study research explores the experience of participants with gangrene wounds who get treatment for wounds with honey. The purpose of this study is to identify the experience of participants when they have gangrenous wounds, the level of comfort, expectations of participants in using wound care with honey. This study uses a phenomenological design. Data collection was carried out by in-depth interviews (in-depth interviews, observations, and documentation studies. The results of verbatim were analyzed by the Colaizzi method. This research took place from July to September 2019. Determination of participants by purposive sampling with 6 participants who used wound care with honey. The research theme was found is The experience of participants when having a gangrenous wound, The experience of participants when getting wound care with honey, The comfort level of participants when using wound care with honey, The hope of participants with wounds when using wound care with honey

Keywords
Gangrene, Wound Care with honey

Topic
Environmental Health and Climate Change

Link: https://ifory.id/abstract/J9NGRQfA2kLy

Corresponding Author
Lanny Sunarjo

Institutions
Poltekkes Kemenkes Semarang

Abstract
Patients who visited the dental clinic complained of oral mucosa ulcus due to trauma, chemical or infection were around 27%. The topical drug available was relatively expensive. It might have side effects for hypersensitive patients. An alternative drug with same efficacy, safe and affordable price was needed. Some research on mangosteen rind showed therapeutic effect as an anti-inflammatory. Objective was to determine role of mangosteen rind paste toward COX (Cyclooxygenase) 2 expression and macrophage on oral mucosa ulcus healing process. This study was an experimental research with 36 male Wistar rats, 3 treatment groups (oral mucosa ulcus due to trauma, chemical and infection) smeared with mangosteen rind paste and 3 control groups. Each group was decapitated on the 3rd, 7th and 10th day and observed microscopically. Data obtained were carried out by statistical tests. Result showed role of mangosteen peel paste significantly reduced COX2 expression and macrophages (p <0.05). Usage of mangosteen rind paste topically could accelerate healing process and prevent excessive inflammation in oral mucosa ulcus

Keywords
oral mucosa ulcus, mangosteen rind, COX2, macrophage

Topic
Drug Discoveries and Development

Link: https://ifory.id/abstract/q4A67kGeYnBD

Corresponding Author
Susan Fitriyana

Institutions
(a) Department of Pharmacology FK Unisba
Jalan Tamansari No. 22 Bandung
(b) Department of Public Health FK Unisba
(c) Department of Physiology FK Unisba
(d) Department of Biochemistry FK Unisa

Abstract
Cigarette smoke is a large source of free radicals and contains high levels of chemical and reactive oxygen species. Exposure to cigarette smoke can cause oxidative stress and inflammation in the lungs, which in turn will cause lung toxicity. This study aims to look at the effect of ethanol extracts of white oyster mushrooms in preventing changes in lymphocyte infiltration in rats exposed to cigarette smoke This experimental study used 32 rats divided into 4 groups. Group I (positive control, only given drinking water and standard food), group II (negative control) were given drinking water, standard food, and exposure to cigarette smoke 1 hour / day / group for 6 weeks. Group III (treatment group) were given cigarette smoke exposure 1 hour / day / group and ethanol extract of white oyster mushroom at a dose of 250 mg / KgBB of mice / day. Group IV (comparison group) were given cigarette smoke exposure 1 hour / day / group and were given N-acetyl cysteine at a dose of 600 mg / day. Lymphocyte infiltration can be seen from the histopathological picture of the lungs of rats treated with haematoxilin eosin staining. The results showed lymphocyte infiltration in rats exposed to cigarette smoke, but there was no significant difference in the proportion of lymphocyte infiltration between all groups (P= 0,14), which was assessed using the Fishers exact test. The conclusions from this study show that ethanol extracts of white oyster mushrooms can prevent changes in lymphocyte infiltration in strain male rats exposed to cigarette smoke exposure.

Keywords
White oyster mushroom ethanol extract, hematological profile, exposure to cigarette smoke

Topic
Drug Discoveries and Development

Link: https://ifory.id/abstract/EQHzLTFCxgwJ

Corresponding Author
Nofal Agnia Dendy

Institutions
1Faculty of Medicine Universitas Islam Bandung
2Clinical Pathology Department, Universitas Islam Bandung
3Public Health Department, Universitas Islam Bandung

Abstract
Scabies is the most common skin disease, which mostly occurs in developing countries. In Indonesia, out of 12 most common skin diseases in Indonesia, scabies is ranked third. Identical scabies disease with diseases that occur in santri in Islamic Boarding Schools, with the incidence of scabies in Islamic Boarding Schools that vary between 13.48% -89.9% and 4.6−12.95%. The level of knowledge and awareness to behave in a clean and healthy life (PHBS) is one of the factors that cause scabies. Based on that this study aims to make a practical module in the form of a "Healthy Santri Pocket Book" containing material about personal hy-giene and scabies to reduce the incidence of scabies in Manarul Huda Islamic Boarding School Bandung as an innovation free scabies boarding school which is expected to become a role model " West Java Islamic Boarding School Healthy, Free of Scabies ". This study is an observational analytic study with a cross-sectional approach. This study aims to assess the knowledge and its effect on the incidence of scabies in santri before and after being given a "Healthy Santri Pocket Book". Pre-test and post-test contain questions about personal hygiene (PHBS) and scabies that are in accordance with the material contained in a healthy santri pocket book. Santri respondents in Manarul Huda Islamic Boarding School in Bandung who were af-fected by scabies before being given the "Healthy Santri Pocket Book" were 27 respondents (81.8%) and af-ter being given "Healthy Santri Pocket Book" there was a decrease in the incidence of scabies to 15 respond-ents (45.4%). In the research results found the pre-test results were 86.67. There was an increase after being given a healthy santri pocket book to 94.8. Based on the results of statistical analysis it can be seen that p <0.05 (P = 0.008) which means that there is an influence on the provision of PHBS material by giving a healthy santri pocket book statistically.

Keywords
Islamic Boarding School, Pocket Book, Scabies.

Topic
Public Health and Occupational Health

Link: https://ifory.id/abstract/Yx7uPTm84w9Q

Corresponding Author
Dede Renovaldi

Institutions
a) Department of Biomedic, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Jakarta,
Jalan KH. Ahmad Dahlan, Ciputat, South Tangerang 15419, Indonesia
*dede.renovaldi[at]gmail.com
b) Department of Clinical Pharmacology, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Jakarta,
Jalan KH. Ahmad Dahlan, Ciputat, South Tangerang 15419, Indonesia
c) Department of Health Community, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Jakarta,
Jalan KH. Ahmad Dahlan, Ciputat, South Tangerang 15419, Indonesia

Abstract
Rifampicin (RIF) is broadly used in the world for the treatment of tuberculosis, but the hepatotoxicity is still a major concern during clinical therapy. Studies showed that RIF induced oxidative stress activity in liver and directly toxic by it-s metabolites. Ocimum americanum (OA) contains phenols, flavonoids, and tannis which act as antioxidants and provides protection against free radicals caused by oxidative damage to cellular components that regulate the formation of ROS molecules. This study attempts to determine the hepatoprotective activity of ethanol extract of Ocimum americanum L. against RIF–induced liver damage in mice. Thereafter, the level serum of biochemical parameters, alanine transaminase (ALT) and aspartate transaminase (AST) were investigated. Treatment groups (RIF 300mg/kgBW + OA 2,8 mg/20grBW and RIF 300mg/kgBW + OA 5,6 mg/20grBW) were compared to RIF group (RIF 300 mg/kgBW) and normal control group. All treatments were given intragastrically for 14 days. Treatment with RIF significantly increased the activities of ALT and AST levels. OA-treatment reduced these activities in both extract dosage groups. However, a significant decrease was only found in serum ALT level. These findings indicate that the ethanol extract of Ocimum americanum L. exerted significant hepatoprotector effects, likely related to its antioxidant compounds.

Keywords
Rifampicin; Ocimum americanum; Hepatoprotector; Antioxidant

Topic
Basic and Clinical Medical Sciences

Link: https://ifory.id/abstract/qWkcCQXmBKeR

Corresponding Author
Wida Purbaningsih

Institutions
a) Histology Department, Faculty of Medicine, Universitas Islam Bandung
b) Microbiology Department, Faculty of Medicine, Universitas Islam Bandung
c) Clinical Pathology Department, Faculty of Medicine, Universitas Islam Bandung

Abstract
Case finding and diagnosis of extrapulmonary tuberculosis are still difficult to enforce because not all medical care facilities can do it. This is because of the microbiological examination of tissue materials requires invasive action and special equipment. Extrapulmonary tuberculosis diagnosis should be made by observing clinical manifestation, microbiological and/or histopathological examinations of samples taken from infected organs through the biopsy process, but in practice, this is not entirely possible. The purpose of this study is to analyze the histopathological feature and microbiological examination of tissue biopsy to establish the extrapulmonary tuberculosis diagnosis in designing parameters for extrapulmonary tuberculosis diagnostic scoring model. Samples were tissue biopsy from extrapulmonary tuberculosis patients. Histopathological preparations used Hematoxylin Eosin staining while microbiological examination of Acid Fast Bacilli stains by ziehl neelsen method. The results showed that based on the degree of positivity of Acid Fast Bacilli stain most have +1. The histopathological feature were almost entirely granuloma and there was a relationship between the degree of Acid Fast Bacilli positivity and histopathology feature. This study concluded that the histopathological feature was related to the results of microbiological examination so that it can be used as a parameter for extrapulmonary tuberculosis diagnostic scoring model design.

Keywords
histopathological,extrapulmonary tuberculosis

Topic
Basic and Clinical Medical Sciences

Link: https://ifory.id/abstract/ZG8nghQT7yKJ

Corresponding Author
yuli susanti

Institutions
1) Public Health Department, Medical Faculty Universitas Islam Bandung, Bandung, Indonesia
*yulisusantiarmandha[at]gmail.com
2) Medical Faculty Universitas Islam Bandung, Bandung, Indonesia
3) Orthopaedic and traumatology Department, Cibabat Hospital, Bandung, Indonesia

Abstract
Background: Work-Related Musculoskeletal Disorder (WRMSDs) are frequent health problem in industrial sector. WRMSDs are associated with work pattern like body position, repetitive movement, and duration of work. This study aims to analyze employment periods and working posture that affect to musculoskeletal disorder in bag fertilizer tailors. Methods: This research is a cross-sectional study carried by observational method. We observe 50 tailors of PT Pupuk Kujang with consecutive random sampling. Data regarding working posture collected using Rapid Upper Limb Assessment (RULA), and musculoskeletal problem assessed with Nordic Body Map (NBM). We analyzed the data using SPSS with chi-square test. Result and discussion: as many as 40% of respondent have employment periods more than 10 years, and 88% of respondent have risk category in working posture. As many as 72% of respondent have musculoskeletal complaints, there are 64% of respondent complain in upper musculoskeletal and 48% have lower musculoskeletal complaint. Based on chi-square test there are no relation between the employment period to musculoskeletal disorder, so as the working posture to musculoskeletal disorder. Conclusion: despite of high percentage of risk category in working posture, there is no correlation to musculoskeletal complaint due to body adaptation to daily working process.

Keywords
posture; nordic body map; musculoskeletal disorder

Topic
Public Health and Occupational Health

Link: https://ifory.id/abstract/kBTcwv8dLxY6

Corresponding Author
Ratna Dewi Astuti

Institutions
Parasitology Department Medical Faculty oh Universitas Islam Bandung

Abstract
Pediculosis capitis is a common disease in Indonesia, especially in pesantren. The high incidence of pediculosis capitis in this pesantren is due to close contact. This study aims to describe the characteristics of santriwati with pediculosis capitis in pesantren as an effort to eradicate pediculosis capitis in pesantren. This research is a cross-sectional study that was conducted at a salafi pesantren in Cililin Kabupaten Bandung Barat in October 2018. Respondents of this study were santriwati with pediculosis capitis. The diagnosis of pediculosis capitis was established by the discovery of adult and or viable eggs lice, while the characteristic of santriwati was obtained by questionnaire. The number of respondents involved was 45 santriwati. The results showed that 44.44% of santriwati got pediculosis capitis in pesantren. As many as 64.44% santriwati also had family with pediculosis capitis in their homes. All santriwati with pediculosis capitis complained of itching on the scalp and 97.78% of santriwati felt ashamed with her pediculosis capitis. All santriwati have done efforts to treat pediculosis capitis. The serit combs was more chosen by santriwati (97.78%) rather than insecticides (42.22%) to treat pediculosis capitis. But appropriate manner of using serit comb that can treat pediculosis capitis is only 44.44%. Pediculosis capitis eradication requires simultaneous appropiate treatment manner both at the pesantren and at home.

Keywords
Eradication, pediculosis capitis, santriwati

Topic
Infectious and Non Infectious Diseases

Link: https://ifory.id/abstract/XRFtLEwquk2d

Corresponding Author
Titik Respati

Institutions
Faculty of Medicine, Universitas Islam Bandung , Bandung, Indonesia
Kummara Game Studio, Bandung, Indonesia

Abstract
Mental health problems in Indonesia are very important public health problems. Stigma on people with mental health disorders is one of the inhibiting factors that needs to be minimized. Adolescents are a group that needs to get this knowledge but become a group that has not received special treatment. The study aims to develop interactive approach (gamification) to support the socialization process and increase understanding on mental health. This is a pre-posttest study design using Carpe Diem Board Game. A total of 24 participants recruited through a purposive sampling and participated in the board game trial. Pre and post-test using the Depression Literacy focuses on two aspects: personal views related to depression and stigma as well as personal beliefs about the views of the surrounding environment related to depression and sigma. The results showed the learning process based on the game gives significant results at each point (pre and posttest changes). When the results of the post-test give little value is an indication that the learning process based on carpe diem that has been done is able to provide understanding and minimize the stigma associated with depression. It is concluded that indicate that game-based learning has an effect although some area still need improvement.

Keywords
Mental health, Adolescent, Carpe Diem Board Game, Indonesia

Topic
Public Health and Occupational Health

Link: https://ifory.id/abstract/aY47Zwceybrq

Corresponding Author
miranti Kania

Institutions
Medical Faculty of Universitas Islam Bandung

Abstract
Introduction: Breast cancer is the most common cancer in women. The incidence of breast cancer has increased sharply throughout the world. In 2012, 1.7 million women were diagnosed with breast cancer, and in the last 5 years there were 6.3 million women diagnosed with breast cancer. The successful rate of standard therapies for breast cancer is currently not optimally achieved, the side effects of breast cancer treatment have also not been overcome, and resistance frequently occurs. The aim of this study are to analysis the potential and protein target of sour soup leaf as breast cancer chemotherapy. Method: This research is bioinformatics study uses the in silico method using the pathway analysis method with Pubchem software, Swiss Target prediction, String and Cytoscope. Result: The result show that of many phytochemical present in soursoup leaf , several phytochemical compound are predicted to act apoptotic, inhibit proliferations, metastasis, and angiogenesis. Conclusion: The conclusion is in silico analysis that soursop leaves component have anticancer activity.

Keywords
Soursop leaves, breast cancer, In silico, Target Therapy

Topic
Drug Discoveries and Development

Link: https://ifory.id/abstract/KGgbVtqwmhYa

Corresponding Author
Fatimah Azzakiyah

Institutions
1) Faculty of Medicine, Universitas Islam Bandung
2) Faculty of Mathematics and Natural Sciences, Universitas Islam Bandung
3) Medical and Molecular Biology, Faculty of Medicine, Universitas Islam Bandung

Abstract
Breast cancer is second leading cause of death for women and in Indonesia can be increase incidence each year. Previous studies has found the used of Curcuma longa as antioxidant, antidiabetic, antiviral even antiangiogenic. The role as antioxidant and antiangiogenic give Curcuma longa as one of potential plant for therapy of cancer. This study aim to know potential therapeutic use of this plant originated from West Java for breast cancer and know the cytotoxic range. Curcuma longa prepared as ethanol extraction using reflux methods. In-vitro investigation used MCF7 cell line. We conduct the cytotoxic examination using MTT assay of the extract to the cell line. Another examination is secondary for secondary metabolites. The screening results give positive for flavonoid and tannin as secondary metabolites and the IC50 from MTT assay of MCF7 is 0.256µg/ml (95% CI 0-3.04µmol). The ethanolic extract turmeric rhizome had high anticancer activity with IC50 values of 0.256µg/ml, revealing that Curcuma longa inhibits MCF7 proliferation. This result shows the potential of Curcuma longa for further research as therapeutic agent for breast cancer.

Keywords
Curcuma longa, breast cancer, therapy of cancer

Topic
Drug Discoveries and Development

Link: https://ifory.id/abstract/KUJZuxqABrEG

Corresponding Author
JOHNATHAN MALAGOBADAN

Institutions
1Asia Metropolitan University, 81750 Johor Bahru,
2School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
3School of Pharmacy, Monash University Malaysia, 47500 Bandar Sunway, Selangor, Malaysia.
4Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
5Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

Abstract
Lignosus rhinocerotis Cooke. (L. rhinocerotis) is a mushroom traditionally used in the treatment of asthma and several other diseases by the indigenous communities in Malaysia. To date, there is limited scientific data on its anti-asthmatic effects. Aim of the study: To evaluate the effects of L. rhinocerotis on airway hyperresponsiveness, inflammation and asthma genes expression in an asthma murine model. Materials and methods: L. rhinocerotis extract (LRE) was prepared by a hot water extraction using a soxhlet. Animal studies were performed using two in vivo models; 1) house dust mite (HDM)-induced mice for evaluationof airway hyperresponsiveness (AHR) and 2) ovalbumin-induced rat for evaluation of airway inflammation. AHR was performed using a whole-body plethysmograph while airway resistance (RI) was measured in response to increasing concentrations of methacholine. Airway inflammation in rats was evaluated by assessing 1) eosinophils, neutrophils and lymphocytes numbers in the bronchoalveolar lavage fluid (BALF) by a flow cytometry, 2) mucus producing goblet cell in the lungs tissue by Periodic acid-Schiff (PAS) staining and 3) asthma pathway related genes expression in the lungs by a quantitative polymerase chain array. Results: Treatment with LRE significantly inhibited AHR in HDM-induced mice. Histological findings revealed that LRE can ameliorate OVA-induced histological changes in rats by attenuating mucus hypersecretion and goblet cell hyperplasia in the lungs. Flow cytometric analysis of BALF indicated that LRE reduced the number of eosinophils and helper T lymphocytes while elevating the number of regulatory T lymphocytes in the BALF. Subsequent analyses on gene expression revealed regulation of several important genes involved in allergy asthma pathway following treatment with LRE. Conclusion: In this study, LRE alleviates airway hyperresponsiveness, airway inflammation and regulates asthma genes expression, thus suggesting its therapeutic potential as a new armamentarium against allergic asthma.

Keywords
Airway hyperresponsiveness, allergic asthma, inflammation, gene expression, Lignosus rhinocerotis

Topic
Drug Discoveries and Development

Link: https://ifory.id/abstract/pGercdRP6z7j

Corresponding Author
Eka Nurhayati

Institutions
1Department of Public Health, Faculty of Medicine, Bandung Islamic University
2Kummara, Bandung

Abstract
This paper presents a design and preliminary results of our initiatives to explore gamification approach to in-crease mental health awareness for Indonesian youth. Consider the current knowledge about mental health among youth in Indonesia, mixed method using both qualitative and quantitative approach was proposed as this research method. These approach is believed to be best to understand stigma on people with mental health disorder among youth.

Keywords
gamification approach, mental health awareness, disorder among youth

Topic
Public Health and Occupational Health

Link: https://ifory.id/abstract/hDLCaKpjPZzt

Corresponding Author
Nurul Romadhona

Institutions
a) and c) Public Health Department, Faculty of Medicine, Bandung Islamic University
b) Clinical Pathology Department, Faculty of Medicine, Bandung Islamic University
d) Histology Department, Faculty of Medicine, Bandung Islamic University Tamansari 22, Bandung, Indonesia, wida7089[at]gmail.com

Abstract
Various efforts have been made by the government to reduce the incidence of tuberculosis (TB) which is still high in Indonesia, ranging from prevention and treatment, but still has not reached the target. Good knowledge and affective of TB patients are expected to reduce TB transmission. The purpose of this study was to analyze the correlation between knowledge and patient attitudes regarding TB. This research method is the Spearman correlation test, with 60 respondents of tuberculosis patients coming to the clinic at one of the hospitals in Bandung Regency, Indonesia. The study was conducted in March 2018. The results of this study found the characteristics of the respondents most women, the most age in the range 18-35 years, the level of higher education, and many who work. Correlation test obtained r value of 0.771, with p 0.014 which means that there is a strong significant correlation with a positive direction. Conclusion The higher the patients knowledge, the better the patients attitude regarding tuberculosis. Attitude is one of the factors that determine a persons behavior. In determining attitudes, knowledge of a particular subject / object is needed. A persons knowledge can be influenced by several factors, including the level of education.

Keywords
attitude, knowledge, tuberculosis

Topic
Public Health and Occupational Health

Link: https://ifory.id/abstract/m7DXB29CUWxZ

Corresponding Author
Ninuk Permata Sari

Institutions
Fakultas Kedokteran Unisba, Fakultas Hukum Unisba, Fakultas Kedokteran Unisba

Abstract
Health services are very closely related to medical secrecy. Medical secrets are basic individual rights that come from human rights, namely the rights of self determination. In the era of disruption, health services underwent a very fundamental change from being conventional to e-health, making them vulnerable to ethical and legal problems. In Indonesia the laws and regulations regarding this matter are not yet fully able to cover the security of medical secrets, so there is a need to update the existing regulations in Indonesia that can guarantee legal certainty of the security of medical secrets. This study aims to find out how far the influence of the era of disruption on the security of medical secrets and how legal certainty is in Indonesia. The research method used is normative juridical, using secondary data consisting of primary legal materials, secondary legal materials and tertiary legal materials such as literature searches in a database of journals, articles, national and international regulations published between 2010-2019. The specifications of this study are descriptive qualitative. The results of this study indicate there is an influence of the era of disruption on the security of medical secrets in Indonesia, including the occurrence of theft and manipulation of patient data and the limited legal certainty. The benefits of this research are expected to be a reference for policy makers to make updates to the regulations in force in Indonesia.

Keywords
legal certainty, security of medical secrets, era of disruption, e-health

Topic
Digital and Health Technology

Link: https://ifory.id/abstract/F74rWUYdqMQe

Corresponding Author
Maya Tejasari

Institutions
a) Histology Department, Faculty of Medicine, Universitas Islam Bandung
Tamansari 22, Bandung, Indonesia, m.tejasari[at]yahoo.com
b) Public Health Department, Faculty of Medicine, Universitas Islam Bandung
c) Biochemistry Department, Faculty of Medicine, Universitas Islam Bandung
d) Physiology Department, Faculty of Medicine, Universitas Islam Bandung

Abstract
MiRNA16 is known to abnormally expressed in liver cancer hepatocellular carcinoma (HCC). Overexpression of miRNA-16 inhibits proliferation, invasion, and metastasis of various cancer cells including live cancer. Monitoring the progress and success of cancer treatment has been high cost. Another consideration is with biomarkers taken from the blood that is minimally invasive. Detection of miRNA levels has potency for the initial diagnosis of malignancy, prognosis prediction and can monitored the therapeutic response because miRNA is very stable in the blood. It was hypothesized that flavonoid from clove leaf oil will be able to interfering MiRNA-16 expression. This study was used the HepG2 cell line culture and treatment groups were given active compound isolated from clove leaf oil. Measurement of gene expression was done with real-time PCR. In this study, the measurement of miRNA-16 expression in liver cancer cell culture after administration of flavonoid pure compounds from clove leaf oil showed an increase in expression almost 24 times the level of expression of the control group. The study conclude that flavonoid compound from clove leaf oil can interfered miRNA-16 expression on liver cancer cells culture.

Keywords
Clove leaf, flavonoid, hepatocellular carcinoma, microRNA-16

Topic
Drug Discoveries and Development

Link: https://ifory.id/abstract/PJBC6AedM4Z3

Corresponding Author
fanny septiani farhan

Institutions
Faculty of Medicine and Health, University of Muhammadiyah Jakarta

Abstract
Background: Stroke is the third largest disease after heart disease and cancer, and the disease is the highest cause of disability in the world. Data from South East Asian Medical Information Centre (SEAMIC) note that the greatest stroke mortality occurred in Indonesia, followed by the Philippines, Singapore, Brunei, Malaysia, and Thailand. Post-stroke disability can be motoric disorders, sensory, autonomic and cognitive disorders. Cognitive impairment caused by stroke can cause interference, such as language disorders, memory, visuospatial, attention, orientation, cognition and emotion. Objective: To investigate impaired cognitive function in stroke patients in departement of neurology, Jakarta Islamic Hospital. Methods: This research is quantitative with cross-sectional design in stroke patients in poly nerve in the Islamic Hospital in Jakarta, Cempaka Putih in September-November 2015 using MoCA-INA (Montreal Cognitive Assessment Version Indonesia) to determine whether or not the function Cognitive respondents take effect. The data were analyzed using univariate to describe each variable. Results: The results of a total of 83 patients with stroke, ischemic stroke is the most common with 75 respondents (90.4%) and with a total of 76 respondents (91.6%) positive impaired cognitive function. For ages, range 55-64 years become the most with 29 respondents (34.9). Under the category of gender, men are more with 47 respondents (56.6%). At the elementary school level is the highest with a total of 22 respondents (26.5%). Conclusion: Based on these results, patients with stroke in Poli Neural Jakarta Islamic Hospital Cempaka Putih, 76 respondents (91.6%) positive impaired cognitive function. Health Waiters are expected to perform routine screening for cognitive function tests for stroke patients in order to diagnose early and assist patients in overcoming the signs and symptoms of cognitive decline

Keywords
Stroke, Cognitive Function Disorders, MoCA-INA

Topic
Infectious and Non Infectious Diseases

Link: https://ifory.id/abstract/YuUj9XJygmaB

Corresponding Author
Arief Budi Yulianti Yulianti

Institutions
Faculty of Medicine, Universitas Islam Bandung

Abstract
Quality of life in adulthood is determined by the quality of life of the embryo. Nutrition determine the quality of embryo life. The purpose of this study was to analyze the effects of unbalance nourishment to memory in mice This research is an experimental study using mice as experimental animals. Twenty four mice divided into 4 groups, Group 1 was given standard nourish (Feed 1), Group 2 was given high carbohydrate (Feed 2), Group 3 was given high protein (Feed 3), Group 4 was given high fat (Feed 4) during puberty until pregnancy. Parameter were measured were body weight and memory with New objects recognition (NOR) methods. The result was unbalance nourishment effected weight body. mice with standard nourish have body weigh more high than mice with unbalance nourish. Meanwhile NOR was inversely, mice with unbalance nourish NOR higher than mice with standard nourish. Carbohydrates, lipids and proteins are components of nutrition, a single nutrient will have a negative impact for healthy.

Keywords
Memory, New object Recognition (NOR), Unbalance nourishment

Topic
Basic and Clinical Medical Sciences

Link: https://ifory.id/abstract/2tYZJnzPjRUu

Corresponding Author
Irma Palupi

Institutions
a) School of Computing, Telkom University
Jl.Telekomunikasi No.1, Kabupaten Bandung.

Abstract
We model the growth of tumor cell in the microscopic point of view by using logistic type of Ordinary Differential Equation. Our model consider proliferative and quiescence type of cell including what we call angiogenic capacity. The parameters of the model will be adjusted by comparing to the experimental data of Ehrlich and fibrosarcoma Sa-37. After obtaining a relevant model, we develop a numerical scheme to simulate effectiveness of chemotherapy drugs to block or to kill proliferative of Tumor cell population.

Keywords
Chemotheraphy respon, Tumor population growth kinetics, Ehrlich and fibrosarcoma Sa-37

Topic
Biomedical and Health Technology

Link: https://ifory.id/abstract/u6qFbARmpCPa

Corresponding Author
Heni Muflihah

Institutions
a) Centenary Institute, University of Sydney, Camperdown, NSW, Australia, 2050
b) Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia, 40116
c) Sydney Medical School, University of Sydney, NSW, Australia, 2006

Abstract
The current Mycobacterium bovis BCG vaccine provides inconsistent protection against pulmonary infection with Mycobacterium tuberculosis (Mtb). In mice studies, immunity induced by subcutaneous BCG wanes by the time. The evidence for immunogenicity following BCG vaccination in Indonesia is limited. This preliminary study measured Mtb-specific T cell response in peripheral blood mononuclear cells (PBMC) using flow cytometry. Three designs were compared in the stimulation of PBMC with Mtb culture filtrate protein (CFP) and additional protein transport inhibitor Brefeldine A (BFA). They were 24 hours or 5 days of CFP stimulation with BFA at the last 4 or 18 hours. The intra-cytoplasmic cytokine staining (ICS) was then performed to assess the production of IFN-gamma, IL-2, and TNF by CD4+ T cells. Single production of IFN-gamma or TNF detected in the 24-hour was higher than that in the 5-day. The 18-hour BFA resulted in a significant proportion of polyfunctional CD4+ T cells. In conclusion, detection of Mtb-specific T cell response using ICS of human PBMC is optimum using 24 hours of antigen stimulation with additional BFA at the last 18 hours. The duration of antigen stimulation and protein transport inhibition affects the amount of intra-cytoplasmic cytokine response analysed using flow cytometry.

Keywords
tuberculosis, CD4+ T cells, intra-cytoptlasmic cytokine

Topic
Infectious and Non Infectious Diseases

Link: https://ifory.id/abstract/VDJEWhZTCjv2

Corresponding Author
Yuktiana Kharisma

Institutions
Departement of Pharmacology Medicine Faculty of Universitas Islam Bandung, Indonesia

Abstract
The coverage of exclusive breastfeeding is still low in Indonesia. Lactagogues are used as an efforts to solve the breastmilk production that can be evaluate indirectly by measuring the young mice growth. Papaya has been use as breastmilk stimulation among Indonesian. Objective of the study is to examine the effect of aqueous extract of unripe papaya fruit on milk production by measuring weight gain and growth of the young mice. The experiment was held at Clinical Pharmacology Laboratory of Padjadjaran University. An experimental study was conducted to 21 lactating mice divided into 3 treatment groups randomly with 10 babies each. First group served as negative control, luteotropin of 6mg/ 30g BW/ day and unripe papaya fruit aqueous extract of 20mg / 30g BW/ day was given orally for the second and third groups respectively. It was started at 4 th -16 th lactation day.The result was analyzed using ANOVA and followed by Tukey test with SPSS 13.00. The babies weight gain in group I, II, and III were 1.25 ± 0.62 g / 6h, 2.25 ± 0.29g / 6h, and 2,21 ± 0.28g / 6h respectively. The growth in group I was 2.95 ± 0.8g/ 2 d; group II was 7.10 ± 0.89g/ 2 d; group III was 5,52 ± 1.53g/ 2 days. The research showed that aqueous extract of unripe papaya fruit has a better effect than negative control (p=0,002) and has an equivalent effect in improving weight gain and growth of mice babies given luteotropin.

Keywords
Papaya, milk production, mice growth.

Topic
Basic and Clinical Medical Sciences

Link: https://ifory.id/abstract/37e9QWaykNgZ

Corresponding Author
Myat Thida Win

Institutions
Asia Metropolitan University

Abstract
Abstract Nowadays, technology is very popular among the younger generations all over the world. Objectives: The objectives of this study are to determine the extent of the influences of smart phones on school children and perception of school children on smart phones. Problem: To explore the smart phone addiction and its association with their health problems, social behavior and academic performance. Methods: The study was carried out using convenient sampling method and using cross sectional study in Malay, Chinese and Tamil primary schools. The questionnaires distributed were composed of total 30 questions. Results: Over half of the school children owned a smart phone. From the social behavior aspect, 145 students disagreed with having emotional changes while away from phone. 166 students supported the idea of not extending the time spent on smart phone. From the academic performance aspect, over half of the respondents agreed to the idea of banning the usage of smart phone in school compound. From the health aspect, 123 students experienced neck pain after using smart phone for a long time; but, only less than half of the respondents 58 agreed to the idea of smart phone causes obesity. Conclusions: Every coin has two sides. The children are not easily influence by the smart phone and their perception are good in the aspect of social behavior and academic performance. However, the students have a moderate perception on smart phone from the aspect of health.

Keywords
Smart phone, Social behavior, Academic performance and Health aspects.

Topic
Digital and Health Technology

Link: https://ifory.id/abstract/J9bTyWD4ztYk